Structure of PDB 6tyf Chain D Binding Site BS03

Receptor Information
>6tyf Chain D (length=1262) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FFDELRIGLATAEDIRQWSYGEVKKPETINYRTLKPEKDGLFCEKIFGPT
RDWECYCGKYKRVRFKGIICERCGVEVTRAKVRRERMGHIELAAPVTHIW
YFKGVPSRLGYLLDLAPKDLEKIIYFAAYVITSVDEEMRHNELSTLEAEM
AVERKAVEDQRDGELEARAQKLEADLAELEAEGAKADARRKVRDGGEREM
RQIRDRAQRELDRLEDIWSTFTKLAPKQLIVDENLYRELVDRYGEYFTGA
MGAESIQKLIENFDIDAEAESLRDVIRNGKGQKKLRALKRLKVVAAFQQS
GNSPMGMVLDAVPVIPPELRPMVQLDGGRFATSDLNDLYRRVINRNNRLK
RLIDLGAPEIIVNNEKRMLQESVDALFDNGRRGRPVTGPGNRPLKSLSDL
LKGKQGRFRQNLLGKRVDYSGRSVIVVGPQLKLHQCGLPKLMALELFKPF
VMKRLVDLNHAQNIKSAKRMVERQRPQVWDVLEEVIAEHPVLLNRAPTLH
RLGIQAFEPMLVEGKAIQLHPLVCEAFNADFDGDQMAVHLPLSAEAQAEA
RILMLSSNNILSPASGRPLAMPRLDMVTGLYYLTTEVPGDTGEYQPASGD
HPETGVYSSPAEAIMAADRGVLSVRAKIKVRLTQLRPPVEIEAELFGHSG
WQPGDAWMAETTLGRVMFNELLPLGYPFVNKQMHKKVQAAIINDLAERYP
MIVVAQTVDKLKDAGFYWATRSGVTVSMADVLVPPRKKEILDHYEERADK
VEKQFQRGALNHDERNEALVEIWKEATDEVGQALREHYPDDNPIITIVDS
GATGNFTQTRTLAGMKGLVTNPKGEFIPRPVKSSFREGLTVLEYFINTHG
ARKGLADTALRTADSGYLTRRLVDVSQDVIVREHDCQTERGIVVELAERA
PDGTLIRDPYIETSAYARTLGTDAVDEAGNVIVERGQDLGDPEIDALLAA
GITQVKVRSVLTCATSTGVCATCYGRSMATGKLVDIGEAVGIVAAQSIGE
PGTQLTGGLPRVQELFEARVPRGKAPIADVTGRVRLEDGERFYKITIVPD
DGGEEVVYDKISKRQRLRVFKHEDGSERVLSDGDHVEVGQQLMEGSADPH
EVLRVQGPREVQIHLVREVQEVYRAQGVSIHDKHIEVIVRQMLRRVTIID
SGSTEFLPGSLIDRAEFEAENRRVVAEGGEPAAGRPVLMGITKASLATDS
WLSAASFQETTRVLTDAAINCRSDKLNGLKENVIIGKLIPAGTGINRYRN
IAVQPTEEARAA
Ligand information
Receptor-Ligand Complex Structure
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PDB6tyf RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription.
Resolution3.8 Å
Binding residue
(original residue number in PDB)		R500 D539
Binding residue
(residue number reindexed from 1)		R495 D534
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6tyf, PDBe:6tyf, PDBj:6tyf
PDBsum6tyf
PubMed32127479
UniProtP9WGY7|RPOC_MYCTU DNA-directed RNA polymerase subunit beta' (Gene Name=rpoC)

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