Structure of PDB 6ovy Chain D Binding Site BS03

Receptor Information
>6ovy Chain D (length=1485) Species: 274 (Thermus thermophilus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EVRKVRIALASPEKIRSWSYGEVEKPETINYRTLKPERDGLFDERIFGPI
KDYECACGKYKRQRFEGKVCERCGVEVTKSIVRRYRMGHIELATPAAHIW
FVKDVPSKIGTLLDLSATELEQVLYFSKYIVLDPKGAILNGVPVEKRQLL
TDEEYRELRYGKQETYPLPPGVDALVKDGEEVVKGQELAPGVVSRLDGVA
LYRFPRRVRVEYVKKERAGLRLPLAAWVEKEAYKPGEILAELPEPYLFRA
EEEGVVELKELEEGAFLVLRREDEPVATYFLPVGMTPLVVHGEIVEKGQP
LAEAKGLLRMPRQVRAAQVEAEEEGETVYLTLFLEWTEPKDYRVQPHMNV
VVPEGARVEAGDKIVAAIDPEEEVIAEAEGVVHLHEPASILVVKARVYPF
EDDVEVSTGDRVAPGDVLADGGKVKSDVYGRVEVDLVRNVVRVVESYDID
ARMGAEAIQQLLKELDLEALEKELLEEMKHPSRARRAKARKRLEVVRAFL
DSGNRPEWMILEAVPVLPPDLRPMVQVDGGRFATSDLNDLYRRLINRNNR
LKKLLAQGAPEIIIRNEKRMLQEAVDALLDNGRRGAPVTNPGSDRPLRSL
TDILSGKQGRFRQNLLGKRVDYSGRSVIVVGPQLKLHQCGLPKRMALELF
KPFLLKKMEEKGIAPNVKAARRMLERQRDIKDEVWDALEEVIHGKVVLLN
RAPTLHRLGIQAFQPVLVEGQSIQLHPLVCEAFNADFDGDQMAVHVPLSS
FAQAEARIQMLSAHNLLSPASGEPLAKPSRDIILGLYYITQVRKEKKGAG
LEFATPEEALAAHERGEVALNAPIKVAGRETSVGRLKYVFANPDEALLAV
AHGIVDLQDVVTVRYMGKRLETSPGRILFARIVAEAVEDEKVAWELIQLD
VPQEKNSLKDLVYQAFLRLGMEKTARLLDALKYYGFTFSTTSGITIGIDD
AVIPEEKKQYLEEADRKLLQIEQAYEMGFLTDRERYDQILQLWTETTEKV
TQAVFKNFEENYPFNPLYVMAQSGARGNPQQIRQLCGLRGLMQKPSGETF
EVPVRSSFREGLTVLEYFISSHGARKGGADTALRTADSGYLTRKLVDVTH
EIVVREADCGTTNYISVPLFQPDEVTRSLRLRKRADIEAGLYGRVLAREV
EVLGVRLEEGRYLSMDDVHLLIKAAEAGEIQEVPVRSPLTCQTRYGVCQK
CYGYDLSMARPVSIGEAVGIVAAQSIGEPGTQLTMTQGLPRVIELFEARR
PKAKAVISEIDGVVRIEETEEKLSVFVESEGFSKEYKLPKEARLLVKDGD
YVEAGQPLTRGAIDPHQLLEAKGPEAVERYLVEEIQKVYRAQGVKLHDKH
IEIVVRQMMKYVEVTDPGDSRLLEGQVLEKWDVEALNERLIAEGKTPVAW
KPLLMGVTKSALSTKSWLSAASFQNTTHVLTEAAIAGKKDELIGLKENVI
LGRLIPAGTGSDFVRFTQVVDQKTLKAIEEARKEA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6ovy Structural basis of reiterative transcription from the pyrG and pyrBI promoters by bacterial RNA polymerase.
Resolution2.999 Å
Binding residue
(original residue number in PDB)		R704 A705 D741 D743
Binding residue
(residue number reindexed from 1)		R701 A702 D738 D740
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6ovy, PDBe:6ovy, PDBj:6ovy
PDBsum6ovy
PubMed31965171
UniProtQ8RQE8|RPOC_THET8 DNA-directed RNA polymerase subunit beta' (Gene Name=rpoC)

[Back to BioLiP]