Structure of PDB 6on2 Chain D Binding Site BS03

Receptor Information

>6on2 Chain D (length=518) Species: 632 (Yersinia pestis)

ALKRKIEAAKMPKDAREKTEAELQKLKMMSPMSAEATVVRGYIDWMLQVP
WNSRSKVKKDLVKAQEVLDTDHYGLERVKDRILEYLAVQSRVSKIKGPIL
CLVGPPGVGKTSLGQSIAKATGRQYVRMALGGVRDEAEIRGHRRTYIGSM
PGKLIQKMAKVGVKNPLFLLDQIDKMASDMRGDPASALLEVLDPEQNVAF
NDHYLEVDYDLSDVMFVATSNSMNIPAPLLDRMEVIRLSGYTEDEKLNIA
KQHLLPKQFERNAIKKGELTIDDSAIMSIIRYYTREAGVRSLEREISKLC
RKAVKNLLMDKTVKHIEINGDNLKDFLGVQKVDTENRVGQVTGLAWTEVG
GDLLTIETACVPGKGKLTYTGSLGEVMQESIQAALTVVRARADKLGINPD
FYEKRDIHVHVPEGATPKDGPSAGIAMCTALVSCLTGNPVRADVAMTGEI
TLRGLVLPIGGLKEKLLAAHRGGIKVVLIPDDNKRDLEEIPDNVIADLEI
HPVKRIDDVLAIALEHPA

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 6on2 Chain D Residue 802

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6on2 Structural basis for distinct operational modes and protease activation in AAA+ protease Lon.
• Resolution: 3.0 Å
• Binding residue (original residue number in PDB): T363 D423
• Binding residue (residue number reindexed from 1): T111 D171
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.4.21.53: endopeptidase La.

Gene Ontology

Molecular Function

• GO:0004176 ATP-dependent peptidase activity
• GO:0004252 serine-type endopeptidase activity
• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity

Biological Process

• GO:0006508 proteolysis
• GO:0030163 protein catabolic process

External links

• PDB: RCSB:6on2, PDBe:6on2, PDBj:6on2
• PDBsum: 6on2
• PubMed: 32490208
• UniProt: A0A5P8YJ65