Structure of PDB 6mm1 Chain D Binding Site BS03

Receptor Information
>6mm1 Chain D (length=135) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SGFEELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAAILKRE
TMRPSSRVALMVLCETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAH
RFHKACVSQLNGMVFCPHCGEDASEAQEVTIPRGD
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6mm1 Chain D Residue 603 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6mm1 The structure of the cysteine-rich region from human histone-lysine N-methyltransferase EHMT2 (G9a).
Resolution1.9 Å
Binding residue
(original residue number in PDB)		C446 C459 C481 H484
Binding residue
(residue number reindexed from 1)		C29 C42 C64 H67
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.367: [histone H3]-lysine(9) N-methyltransferase.
Gene Ontology
Molecular Function
GO:0002039 p53 binding
GO:0008270 zinc ion binding
GO:0016279 protein-lysine N-methyltransferase activity
GO:0042054 histone methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:6mm1, PDBe:6mm1, PDBj:6mm1
PDBsum6mm1
PubMed34278292
UniProtQ96KQ7|EHMT2_HUMAN Histone-lysine N-methyltransferase EHMT2 (Gene Name=EHMT2)

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