Structure of PDB 6fog Chain D Binding Site BS03

Receptor Information
>6fog Chain D (length=215) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PLSRFWEWGKNIVCVGRNYADHVREMRSAVLSEPVLFLKPSTAYAPEGSP
ILMPAYTRNLHHELELGVVMGKRCRAVPEAAAMDYVGGYALCLDMTARDV
QDECKKKGLPWTLAKSFTASCPVSAFVPKEKIPDPHKLKLWLKVNGELRQ
EGETSSMIFSIPYIISYVSKIITLEEGDIILTGTPKGVGPVKENDEIEAG
IHGLVSMTFKVEKPE
Ligand information
Ligand IDOXL
InChIInChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2
InChIKeyMUBZPKHOEPUJKR-UHFFFAOYSA-L
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341		[O-]C(=O)C([O-])=O
OpenEye OEToolkits 1.5.0C(=O)(C(=O)[O-])[O-]
FormulaC2 O4
NameOXALATE ION
ChEMBL
DrugBank
ZINC
PDB chain6fog Chain D Residue 303 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6fog Structural basis for the bi-functionality of human oxaloacetate decarboxylase FAHD1.
Resolution1.94 Å
Binding residue
(original residue number in PDB)		G24 E71 K123 T192
Binding residue
(residue number reindexed from 1)		G16 E63 K115 T184
Annotation score2
Enzymatic activity
Enzyme Commision number 3.7.1.5: acylpyruvate hydrolase.
4.1.1.112: oxaloacetate decarboxylase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008948 oxaloacetate decarboxylase activity
GO:0016787 hydrolase activity
GO:0016829 lyase activity
GO:0016853 isomerase activity
GO:0018773 acetylpyruvate hydrolase activity
GO:0034545 fumarylpyruvate hydrolase activity
GO:0046872 metal ion binding
GO:0047621 acylpyruvate hydrolase activity
GO:0050163 oxaloacetate tautomerase activity
Biological Process
GO:0006090 pyruvate metabolic process
GO:0006107 oxaloacetate metabolic process
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6fog, PDBe:6fog, PDBj:6fog
PDBsum6fog
PubMed30348641
UniProtQ6P587|FAHD1_HUMAN Oxaloacetate tautomerase FAHD1, mitochondrial (Gene Name=FAHD1)

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