Structure of PDB 5zdp Chain D Binding Site BS03

Receptor Information
>5zdp Chain D (length=265) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PVWGHTQLNRLSFLETVPVVPLRVSDESSEDRPTWSLPDIENVAITHKKP
NGLVDTLAYRSVRTCRWLFDTFSLYRFGSITESKVISRCLFLETVAGVPG
MVGGMLRHLSSLRYMTRDKGWINTLLVEAENERMHLMTFIELRQPGLPLR
VSIIITQAIMYLFLLVAYVISPRFVHRFVGYLEEEAVITYTGVMRAIDEG
RLRPTKNDVPEVARVYWNLSKNATFRDLINVIRADEAEHRVVNHTFADMH
EKRLQNSVNPFVVLK
Ligand information
Ligand IDOXY
InChIInChI=1S/O2/c1-2
InChIKeyMYMOFIZGZYHOMD-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341
OpenEye OEToolkits 1.5.0		O=O
FormulaO2
NameOXYGEN MOLECULE
ChEMBLCHEMBL1234886
DrugBankDB09140
ZINC
PDB chain5zdp Chain D Residue 504 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5zdp Insights into the ubiquinol/dioxygen binding and proton relay pathways of the alternative oxidase.
Resolution2.71 Å
Binding residue
(original residue number in PDB)		A126 E213
Binding residue
(residue number reindexed from 1)		A96 E183
Annotation score4
Enzymatic activity
Enzyme Commision number 1.-.-.-
Gene Ontology
Molecular Function
GO:0008199 ferric iron binding
GO:0009916 alternative oxidase activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0010230 alternative respiration
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5zdp, PDBe:5zdp, PDBj:5zdp
PDBsum5zdp
PubMed30910528
UniProtQ26710|AOX_TRYBB Alternative oxidase, mitochondrial (Gene Name=AOX)

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