Structure of PDB 5vi5 Chain D Binding Site BS03

Receptor Information
>5vi5 Chain D (length=1238) Species: 246196 (Mycolicibacterium smegmatis MC2 155) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VNFFDELRIGLATADDIRNWSYGEVKKPETINYRTLKPEKDGLFCEKIFG
PTRDWECYCGKYKRVRFKGIICERCGVEVTRAKVRRERMGHIELAAPVTH
IWYFKGVPSRLGYLLDLAPKDLEKIIYFAAYVITSVDDEMRHNELSTLEA
EMAVEKKAVEDQRDADLEARAQKLEADLAELEAEGAKSDVRRKVRDSGER
EMRQLRDRAQRELDRLDEIWNTFTKLAPKQLIVDEVLYRELQDRYGEYFT
GAMGAESIKKLIENFDIDAEAESLREVIRSGKKLRALKRLKVVAAFQQSG
NSPMGMVLDAVPVIPPELRPMVQLDGGRFATSDLNDLYRRVINRNNRLKR
LIDLGAPEIIVNNEKRMLQESVDALFDNGRRGRPVTGPGNRPLKSLSDLL
KGKQGRFRQNLLGKRVDYSGRSVIVVGPQLKLHQCGLPKLMALELFKPFV
MKRLVDLNHAQNIKSAKRMVERQRPQVWDVLEEVIAEHPVLLNRAPTLHR
LGIQAFEPQLVEGKAIQLHPLVCEAFNADFDGDQMAVHLPLSAEAQAEAR
ILMLSSNNILSPASGKPLAMPRLDMVTGLYYLTTLVEGATGEYQAATKDA
PEQGVYSSPAEAIMAMDRGALSVRAKIKVRLTELRPPTDLEAQLFENGWK
PGDAWTEETTLGRVMFNELLPKSYPFVNEQMHKKVQARIINDLAERFPMI
VVAQTVDKLKDAGFYWATRSGVTVSMADVLVPPQKQEILERHEAEADAIE
RKYHTERNESLVKIWQDATEEVGKALEEFYPADNPIITIVKSGATGNLTQ
TRTLAGMKGLVTNPKGEFIPRPIKSSFREGLTVLEYFINTHGARKGLADT
ALRTADSGYLTRRLVDVSQDVIVREHDCETERGINVTLAERGPDIRDAHV
ETSAFARTLATDAVDANGNVIIERGHDLGDPAIDALLAAGITTVKVRSVL
TCTSATGVCAMCYGRSMATGKLVDIGEAVGIVAAQSIGEPGTQLTGGLPR
VQELFEARVPRNKAPIADVAGRVRLEESDKFFKITIVPDDGGEEVVYDKL
SKRQRLRVGVLSDGDHVEVGDQLMEGAADPHEVLRVQGPREVQIHLVKEV
QEVYRAQGVSIHDKHIEVIVRQMLRRVTIIDSGSTEFLPGSLTERAEFEA
ENRRVVAAGRPVLMGITKASLATDSWLSAASFQETTRVLTDAAINCRSDK
LNGLKENVIIGKLIPAGTGISRYRNINVQPTEEARAAA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5vi5 Structural insights into the mycobacteria transcription initiation complex from analysis of X-ray crystal structures.
Resolution3.196 Å
Binding residue
(original residue number in PDB)		D537 D539
Binding residue
(residue number reindexed from 1)		D531 D533
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5vi5, PDBe:5vi5, PDBj:5vi5
PDBsum5vi5
PubMed28703128
UniProtA0QS66|RPOC_MYCS2 DNA-directed RNA polymerase subunit beta' (Gene Name=rpoC)

[Back to BioLiP]