Structure of PDB 4koe Chain D Binding Site BS03

Receptor Information
>4koe Chain D (length=207) Species: 170187 (Streptococcus pneumoniae TIGR4) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTAK
AKMADILKNEEINTMIYTIGAGVGADFSIEDANYDKIIIMTDADTDGAHI
QTLLLTFFYRYMRPLVEAGHVYIALPPLYKYAWTDGELEELRKQQRYKGL
GEMNADQLWETTMNPETRTLIRVTIEDLARAERRVNVLMGDKVEPRRKWI
EDNVKFT
Ligand information
Receptor-Ligand Complex Structure
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PDB4koe Inhibitor-stabilised cleavage complexes of topoisomerase IIa: structural analysis of drug-dependent inter- and intramolecular interactions
Resolution3.02 Å
Binding residue
(original residue number in PDB)		K458 I460 N461 K464 N473 H513 R629
Binding residue
(residue number reindexed from 1)		K44 I46 N47 K50 N59 H99 R196
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:4koe, PDBe:4koe, PDBj:4koe
PDBsum4koe
PubMed
UniProtQ59961|PARE_STRPN DNA topoisomerase 4 subunit B (Gene Name=parE)

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