Structure of PDB 4bw5 Chain D Binding Site BS03

Receptor Information
>4bw5 Chain D (length=250) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KWKTVVAIFVVVVVYLVTGGLVFRALEQPFESSQKNTIALEKAEFLRDHV
CVSPQELETLIQHALDADNAGVSPISHWDLGSAFFFAGTVITTIGYGNIA
PSTEGGKIFCILYAIFGIPLFGFLLAGIGDQLGTIFGKSIARVEKVFRKK
QVSQTKIRVISTILFILAGCIVFVTIPAVIFKYIEGWTALESIYFVVVTL
TTVGFGDFVAGGNYREWYKPLVWFWILVGLAYFAAVLSMIGDWLRVLSKK
Ligand information
Ligand IDK
InChIInChI=1S/K/q+1
InChIKeyNPYPAHLBTDXSSS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[K+]
FormulaK
NamePOTASSIUM ION
ChEMBLCHEMBL1233793
DrugBankDB01345
ZINC
PDB chain4bw5 Chain C Residue 602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4bw5 K2P Channel Gating Mechanisms Revealed by Structures of Trek-2 and a Complex with Prozac
Resolution3.2 Å
Binding residue
(original residue number in PDB)		T172 I173 G174 T281 V282
Binding residue
(residue number reindexed from 1)		T93 I94 G95 T202 V203
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005267 potassium channel activity
Biological Process
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4bw5, PDBe:4bw5, PDBj:4bw5
PDBsum4bw5
PubMed25766236
UniProtP57789|KCNKA_HUMAN Potassium channel subfamily K member 10 (Gene Name=KCNK10)

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