Structure of PDB 3rae Chain D Binding Site BS03

Receptor Information
>3rae Chain D (length=209) Species: 1313 (Streptococcus pneumoniae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTAK
AKMADILKNEEINTMIYTIGAGVGADFSIEDANYDKIIIMTDADTDGAHI
QTLLLTFFYRYMRPLVEAGHVYIALPPLYKMYAWTDGELEELRKQLQRYK
GLGEMNADQLWETTMNPETRTLIRVTIEDLARAERRVNVLMGDKVEPRRK
WIEDNVKFT
Ligand information
Receptor-Ligand Complex Structure
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PDB3rae Structure of a quinolone-stabilized cleavage complex of topoisomerase IV from Klebsiella pneumoniae and comparison with a related Streptococcus pneumoniae complex.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		K458 I460 N461 K464 H513 V626 R629
Binding residue
(residue number reindexed from 1)		K44 I46 N47 K50 H99 V195 R198
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:3rae, PDBe:3rae, PDBj:3rae
PDBsum3rae
PubMed27050128
UniProtQ59961|PARE_STRPN DNA topoisomerase 4 subunit B (Gene Name=parE)

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