Structure of PDB 3ksa Chain D Binding Site BS03

Receptor Information

>3ksa Chain D (length=218) Species: 1313 (Streptococcus pneumoniae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

KLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTAK
AKMADILKNEEINTMIYTIGAGVDFSIEANYDKIIIMTDADTDGAHIQTL
LLTFFYRYMRPLVEAGHVYIALPPLYKMSKEEVAYAWTDGELEELRKQFG
KGATLQRYKGLGEMNADQLWETTMNPETRTLIRVTIEDLARAERRVNVLM
GDKVEPRRKWIEDNVKFT

Ligand information

>3ksa Chain H (length=11) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

gactatgcacg

Receptor-Ligand Complex Structure

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Structure summary

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PDB	3ksa Structural Basis of Gate-DNA Breakage and Resealing by Type II Topoisomerases
Resolution	3.3 Å
Binding residue (original residue number in PDB)	K458 I460 N461 K464 H513 V626 R629
Binding residue (residue number reindexed from 1)	K44 I46 N47 K50 H96 V204 R207

Enzymatic activity

Enzyme Commision number

5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524	ATP binding

	Biological Process
GO:0006265	DNA topological change

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Molecular Function

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Biological Process

External links

PDB	RCSB:3ksa, PDBe:3ksa, PDBj:3ksa
PDBsum	3ksa
PubMed	20596531
UniProt	Q59961\|PARE_STRPN DNA topoisomerase 4 subunit B (Gene Name=parE)

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