Structure of PDB 3htx Chain D Binding Site BS03

Receptor Information
>3htx Chain D (length=795) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HTPTPKAIIHQKFGAKASYTVEEVHDSSQSGCPGLAIPQKGPCLYRCHLQ
LPEFSVVSNVFKKKKDSEQSAAELALDKLGIRPQNDDLTVDEARDEIVGR
IKYIFSDEFLSAEHPLGAHLRAALRRDGERCGSVPVSVIATVDAKINSRC
KIINPSVESDPFLAISYVMKAAAKLADYIVASPHGLRRKNAYPSEIVEAL
ATHVSDSLHSREVAAVYIPCIDEEVVELDTLYISSNRHYLDSIAERLGLK
DGNQVMISRMFGKASCGSECRLYSEIPKKYLDNSSIVKSRNARASYICGQ
DIHGDAILASVGYRWKSDDLDYDDVTVNSFYRICCGMSPNGIYKISRQAV
IAAQLPFAFTTKSNWRGPLPREILGLFCHQHRLAEPILSSSRCEVKIFTK
SQDLVLECSPRKFYEKENDAIQNASLKALLWFSKFFADLSPNVFAAPPSS
ESKEKRVQSITNGSVVSICYSLSLAVDPEYESSVEPIESNEEIEFEVGTG
SMNPHIESEVTQMTVGEYASFKMTPPDAAEALILAVGSDTVRIRSLLSER
PCLNYNILLLGVKGPSEERMEAAFFKPPLSKQRVEYALKHIRESSASTLV
DFGCGSGSLLDSLLDYPTSLQTIIGVDISPKGLARAAKMLHVKLNKEACN
VKSATLYDGSILEFDSRLHDVDIGTCLEVIEHMEEDQACEFGEKVLSLFH
PKLLIVSTPNYEFNTILQRSTLPKFRNHDHKFEWTREQFNQWASKLGKRH
NYSVEFSGVGGSGEVEPGFASQIAIFRREESSMQPYKVIWEWKKE
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain3htx Chain D Residue 950 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3htx Structural insights into mechanisms of the small RNA methyltransferase HEN1.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		E796 E799 H800 H860
Binding residue
(residue number reindexed from 1)		E678 E681 H682 H730
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.386: small RNA 2'-O-methyltransferase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0008168 methyltransferase activity
GO:0008171 O-methyltransferase activity
GO:0008173 RNA methyltransferase activity
GO:0046872 metal ion binding
GO:0090486 small RNA 2'-O-methyltransferase activity
Biological Process
GO:0001510 RNA methylation
GO:0009616 RNAi-mediated antiviral immune response
GO:0009909 regulation of flower development
GO:0010093 specification of floral organ identity
GO:0010267 ta-siRNA processing
GO:0010305 leaf vascular tissue pattern formation
GO:0010589 leaf proximal/distal pattern formation
GO:0016070 RNA metabolic process
GO:0031047 regulatory ncRNA-mediated gene silencing
GO:0032259 methylation
GO:0035196 miRNA processing
GO:0035279 miRNA-mediated gene silencing by mRNA destabilization
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3htx, PDBe:3htx, PDBj:3htx
PDBsum3htx
PubMed19812675
UniProtQ9C5Q8|HEN1_ARATH Small RNA 2'-O-methyltransferase (Gene Name=HEN1)

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