Structure of PDB 2y9x Chain D Binding Site BS03

Receptor Information
>2y9x Chain D (length=391) Species: 5341 (Agaricus bisporus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SDKKSLMPLVGIPGEIKNRLNILDFVKNDKFFTLYVRALQVLQARDQSDY
SSFFQLGGIHGLPYTEWAKAQPQLHLYKANYCTHGTVLFPTWHRAYESTW
EQTLWEAAGTVAQRFTTSDQAEWIQAAKDLRQPFWDWGYWPNDPDFIGLP
DQVIRDKQVEITDYNGTKIEVENPILHYKFHPIEPTFEGDFAQWQTTMRY
PDVQKQENIEGMIAGIKAAAPGFREWTFNMLTKNYTWELFSNHGAVVGAH
ANSLEMVHNTVHFLIGRDPTLDPLVPGHMGSVPHAAFDPIFWMHHCNVDR
LLALWQTMNYDVYVSEGMNREATMGLIPGQVLTEDSPLEPFYTKNQDPWQ
SDDLEDWETLGFSYPDFDPVKGKSKEEKSVYINDWVHKHYG
Ligand information
Ligand ID0TR
InChIInChI=1S/C7H6O2/c8-6-4-2-1-3-5-7(6)9/h1-5H,(H,8,9)
InChIKeyMDYOLVRUBBJPFM-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.352OC1=CC=CC=CC1=O
OpenEye OEToolkits 1.6.1C1=CC=C(C(=O)C=C1)O
FormulaC7 H6 O2
Name2-HYDROXYCYCLOHEPTA-2,4,6-TRIEN-1-ONE;
TROPOLONE
ChEMBLCHEMBL121188
DrugBank
ZINCZINC000000392003
PDB chain2y9x Chain D Residue 410 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2y9x Crystal Structure of Agaricus Bisporus Mushroom Tyrosinase: Identity of the Tetramer Subunits and Interaction with Tropolone.
Resolution2.78 Å
Binding residue
(original residue number in PDB)		H85 H259 N260 H263 M280 S282 V283 A286
Binding residue
(residue number reindexed from 1)		H84 H258 N259 H262 M279 S281 V282 A285
Annotation score1
Enzymatic activity
Enzyme Commision number 1.14.18.1: tyrosinase.
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity

View graph for
Molecular Function
External links
PDB RCSB:2y9x, PDBe:2y9x, PDBj:2y9x
PDBsum2y9x
PubMed21598903
UniProtC7FF04|PPO3_AGABI Polyphenol oxidase 3 (Gene Name=PPO3)

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