Structure of PDB 1zbh Chain D Binding Site BS03

Receptor Information
>1zbh Chain D (length=289) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DFSDPVYKEIAITNGCINRMSKEELRAKLSEFKLETRGVKDVLKKRLKNY
YKKQKLMLKESNFADSYYDYICIIDFEATCEEGNPPEFVHEIIEFPVVLL
NTHTLEIEDTFQQYVRPEINTQLSDFCISLTGITQDQVDRADTFPQVLKK
VIDLMKLKELGTKYKYSLLTDGSWDMSKFLNIQCQLSRLKYPPFAKKWIN
IRKSYGNFYKVPRSQTKLTIMLEKLGMDYDGRPNCGLDDSKNIARIAVRM
LQDGCELRINEKMHAGQLMSVSSSLPIEGTPPPQMPHFR
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain1zbh Chain D Residue 4001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1zbh Structural basis for 3'-end specific recognition of histone mRNA stem-loop by 3'-exonuclease, a human nuclease that also targets siRNA
Resolution3.0 Å
Binding residue
(original residue number in PDB)		D134 E136 D298
Binding residue
(residue number reindexed from 1)		D75 E77 D239
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) D134 E136 D234 N293 D298
Catalytic site (residue number reindexed from 1) D75 E77 D175 N234 D239
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0000175 3'-5'-RNA exonuclease activity
GO:0003676 nucleic acid binding

View graph for
Molecular Function
External links
PDB RCSB:1zbh, PDBe:1zbh, PDBj:1zbh
PDBsum1zbh
PubMed
UniProtQ8IV48|ERI1_HUMAN 3'-5' exoribonuclease 1 (Gene Name=ERI1)

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