Structure of PDB 1z03 Chain D Binding Site BS03

Receptor Information
>1z03 Chain D (length=427) Species: 303 (Pseudomonas putida) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ISDARANNAKTQSQYQPYKDAAWGFINHWYPALFTHELEEDQVQGIQICG
VPIVLRRVNGKVFALKDQCLHRGVRLSEKPTCFTKSTISCWYHGFTFDLE
TGKLVTIVANPEDKLIGTTGVTTYPVHEVNGMIFVFVREDDFPDEDVPPL
AHDLPFRFPERSEQFPHPLWPSSPSVLDDNAVVHGMHRTGFGNWRIACEN
GFDNAHILVHKDNTIVHAMDWVLPLGLLPTSDDCIAVVEDDDGPKGMMQW
LFTDKWAPVLENQELGLKVEGLKGRHYRTSVVLPGVLMVENWPEEHVVQY
EWYVPITDDTHEYWEILVRVCPTDEDRKKFQYRYDHMYKPLCLHGFNDSD
LYAREAMQNFYYDGTGWDDEQLVATDISPITWRKLASRWNRGIAKPGRGV
AGAVKDTSLIFKQTADGKRPGYKVEQI
Ligand information
Ligand IDOCH
InChIInChI=1S/C9H7NO/c11-9-6-5-7-3-1-2-4-8(7)10-9/h1-6H,(H,10,11)
InChIKeyLISFMEBWQUVKPJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1ccc2c(c1)C=CC(=O)N2
CACTVS 3.341O=C1Nc2ccccc2C=C1
ACDLabs 10.04O=C2C=Cc1c(cccc1)N2
FormulaC9 H7 N O
NameQUINOLIN-2(1H)-ONE;
2-OXOQUINOLINE
ChEMBLCHEMBL186422
DrugBankDB04745
ZINCZINC000008579298
PDB chain1z03 Chain D Residue 4603 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1z03 2-Oxoquinoline 8-Monooxygenase Oxygenase Component: Active Site Modulation by Rieske-[2Fe-2S] Center Oxidation/Reduction
Resolution1.8 Å
Binding residue
(original residue number in PDB)		G216 V304 W307 Q314
Binding residue
(residue number reindexed from 1)		G201 V289 W292 Q299
Annotation score5
Enzymatic activity
Enzyme Commision number 1.14.13.61: 2-hydroxyquinoline 8-monooxygenase.
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0051537 2 iron, 2 sulfur cluster binding

View graph for
Molecular Function
External links
PDB RCSB:1z03, PDBe:1z03, PDBj:1z03
PDBsum1z03
PubMed15893671
UniProtO05935

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