Structure of PDB 1s77 Chain D Binding Site BS03

Receptor Information
>1s77 Chain D (length=828) Species: 10760 (Escherichia phage T7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SDIELAAIPFNTLADHYGERLAREQLALEHESYEMGEARFRKMFERQLKA
GEVADNAAAKPLITTLLPKMIARINDWFEEVKAKRGKRPTAFQFLQEIKP
EAVAYITIKTTLACLTSADNTTVQAVASAIGRAIEDEARFGRIRDLEAKH
FKKNVEEQLNKRVGHVYKKAFMQVVEADMLSKGAWSSWHKEDSIHVGVRC
IEMLIESTGMVSLHSETIELAPEYAEAIATRAGALAGISPMFQPCVVPPK
PWTGITGGGYWANGRRPLALVRTHSKKALMRYEDVYMPEVYKAINIAQNT
AWKINKKVLAVANVITKWKHCPVEDIPAIEREELPWKRAAAAVYRKDKAR
KSRRISLEFMLEQANKFANHKAIWFPYNMDWRGRVYAVSMFNPQGNDMTK
GLLTLAKGKPIGKEGYYWLKIHGANCAGVDKVPFPERIKFIEENHENIMA
CAKSPLENTWWAEQDSPFCFLAFCFEYAGVQHHGLSYNCSLPLAFDGSCS
GIQHFSAMLRDEVGGRAVNLLPSETVQDIYGIVAKKVNEILQADAINGTD
NEVVKLGTKALAGQWLAYGVTRSVTKRSVMTLAYGSKEFGFRQQVLEDTI
QPAIDSGKGLMFTQPNQAAGYMAKLIWESVSVTVVAAVEAMNWLKSAAKL
LAAEVKDKKTGEILRKRCAVHWVTPDGFPVWQEYKKPIQTRLNLMFLGQF
RLQPTINTNKDSEIDAHKQESGIAPNFVHSQDGSHLRKTVVWAHEKYGIE
SFALIHDSFGTIPADAANLFKAVRETMVDTYESCDVLADFYDQFADQLHE
SQLDKMPALPAKGNLNLRDILESDFAFA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1s77 The structural mechanism of translocation and helicase activity in T7 RNA polymerase.
Resolution2.69 Å
Binding residue
(original residue number in PDB)
Q169 K172 A390 R394 K441 S541 M635 Y639 R746 Q754 H784 H811 D812
Binding residue
(residue number reindexed from 1)
Q158 K161 A349 R353 K400 S500 M580 Y584 R691 Q699 H729 H756 D757
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039695 DNA-templated viral transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:1s77, PDBe:1s77, PDBj:1s77
PDBsum1s77
PubMed15016374
UniProtP00573|RPOL_BPT7 T7 RNA polymerase (Gene Name=1)

[Back to BioLiP]