Structure of PDB 1msw Chain D Binding Site BS03

Receptor Information
>1msw Chain D (length=863) Species: 10760 (Escherichia phage T7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NTINIAKNDFSDIELAAIPFNTLADHYGERLAREQLALEHESYEMGEARF
RKMFERQLKAGEVADNAAAKPLITTLLPKMIARINDWFEEVKAKRGKRPT
AFQFLQEIKPEAVAYITIKTTLACLTSADNTTVQAVASAIGRAIEDEARF
GRIRDLEAKHFKKNVEEQLNKRVGHVYKKAFMQVVEADMLSKGLLGGEAW
SSWHKEDSIHVGVRCIEMLIESTGMVSLHRQSETIELAPEYAEAIATRAG
ALAGISPMFQPCVVPPKPWTGITGGGYWANGRRPLALVRTHSKKALMRYE
DVYMPEVYKAINIAQNTAWKINKKVLAVANVITKWKHCPVEDIPAIEREE
LPMKTAWKRAAAAVYRKDKARKSRRISLEFMLEQANKFANHKAIWFPYNM
DWRGRVYAVSMFNPQGNDMTKGLLTLAKGKPIGKEGYYWLKIHGANCAGV
DKVPFPERIKFIEENHENIMACAKSPLENTWWAEQDSPFCFLAFCFEYAG
VQHHGLSYNCSLPLAFDGSCSGIQHFSAMLRDEVGGRAVNLLPSETVQDI
YGIVAKKVNEILQADAINGTDNEVVTVTDENTGEISEKVKLGTKALAGQW
LAYGVTRSVTKRSVMTLAYGSKEFGFRQQVLEDTIQPAIDSGKGLMFTQP
NQAAGYMAKLIWESVSVTVVAAVEAMNWLKSAAKLLAAEVKDKKTGEILR
KRCAVHWVTPDGFPVWQEYKKPIQTRLNLMFLGQFRLQPTINTNKDSEID
AHKQESGIAPNFVHSQDGSHLRKTVVWAHEKYGIESFALIHDSFGTIPAD
AANLFKAVRETMVDTYESCDVLADFYDQFADQLHESQLDKMPALPAKGNL
NLRDILESDFAFA
Ligand information
Receptor-Ligand Complex Structure
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PDB1msw Structural Basis for the Transition from Initiation to Elongation Transcription in T7 RNA Polymerase
Resolution2.1 Å
Binding residue
(original residue number in PDB)		N171 S301 K389 A390 S393 R394 R425 Y639 R756 I810 H811 D812
Binding residue
(residue number reindexed from 1)		N170 S292 K369 A370 S373 R374 R405 Y619 R736 I790 H791 D792
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039695 DNA-templated viral transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Biological Process
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Cellular Component
External links
PDB RCSB:1msw, PDBe:1msw, PDBj:1msw
PDBsum1msw
PubMed12242451
UniProtP00573|RPOL_BPT7 T7 RNA polymerase (Gene Name=1)

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