Structure of PDB 1c0w Chain D Binding Site BS03

Receptor Information

>1c0w Chain D (length=175) Species: 1717 (Corynebacterium diphtheriae)

KDLVDTTEMYLRTIYELEEEGVTPLRARIAERLEQSGPTVSQTVARMERD
GLVVVASDRSLQMTPTGRTLATAVMRKHRLAERLLTDIIGLDINKVHDEA
CRWEHVMSDEVERRLVKVLKDVSRSPFGNPIPGLDELGVVQINEIFQVET
DQFTQLLDADIRVVELLDDLAHTIR

Ligand information

• Ligand ID: CO
• InChI: InChI=1S/Co/q+2
• InChIKey: XLJKHNWPARRRJB-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Co+2]
  CACTVS 3.341: [Co++]
• Formula: Co
• Name: COBALT (II) ION
• DrugBank: DB14205
• PDB chain: 1c0w Chain D Residue 604

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1c0w Crystal structure of a cobalt-activated diphtheria toxin repressor-DNA complex reveals a metal-binding SH3-like domain.
• Resolution: 3.2 Å
• Binding residue (original residue number in PDB): H79 E83 H98 E170 Q173
• Binding residue (residue number reindexed from 1): H78 E82 H97 E144 Q147
• Annotation score: 3

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003700 DNA-binding transcription factor activity
• GO:0017124 SH3 domain binding
• GO:0042802 identical protein binding
• GO:0046914 transition metal ion binding
• GO:0046983 protein dimerization activity

Biological Process

• GO:0006355 regulation of DNA-templated transcription
• GO:0045892 negative regulation of DNA-templated transcription

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:1c0w, PDBe:1c0w, PDBj:1c0w
• PDBsum: 1c0w
• PubMed: 10497029
• UniProt: P0DJL7|DTXR_CORDI Diphtheria toxin repressor (Gene Name=dtxR)