Structure of PDB 1atn Chain D Binding Site BS03

Receptor Information
>1atn Chain D (length=258) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LKIAAFNIRTFGETKMSNATLASYIVRIVRRYDIVLIQEVRDSHLVAVGK
LLDYLNQDDPNTYHYVVSEPLGRNSYKERYLFLFRPNKVSVLDTYQYDDG
CCGNDSFSREPAVVKFSSHSTKVKEFAIVALHSAPSDAVAEINSLYDVYL
DVQQKWHLNDVMLMGDFNADCSYVTSSQWSSIRLRTSSTFQWLIPDSADT
TATSTNCAYDRIVVAGSLLQSSVVPGSAAPFDFQAAYGLSNEMALAISDH
YPVEVTLT
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain1atn Chain D Residue 266 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1atn Atomic structure of the actin:DNase I complex.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		D172 D198 N208
Binding residue
(residue number reindexed from 1)		D170 D196 N206
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.21.1: deoxyribonuclease I.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003779 actin binding
GO:0003824 catalytic activity
GO:0004519 endonuclease activity
GO:0004530 deoxyribonuclease I activity
GO:0004536 DNA nuclease activity
GO:0005515 protein binding
Biological Process
GO:0002283 neutrophil activation involved in immune response
GO:0002673 regulation of acute inflammatory response
GO:0006308 DNA catabolic process
GO:0006915 apoptotic process
GO:0070948 regulation of neutrophil mediated cytotoxicity
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0031410 cytoplasmic vesicle
GO:0042588 zymogen granule

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1atn, PDBe:1atn, PDBj:1atn
PDBsum1atn
PubMed2395459
UniProtP00639|DNAS1_BOVIN Deoxyribonuclease-1 (Gene Name=DNASE1)

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