Structure of PDB 1agr Chain D Binding Site BS03
Receptor Information
>1agr Chain D (length=344) Species:
10116
(Rattus norvegicus) [
Search protein sequence
] [
Download receptor structure
] [
Download structure with residue number starting from 1
] [
View receptor structure
]
AAVERSKMIDRNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEAG
YSEEECKQYKAVVYSNTIQSIIAIIRAMGRLKIDFGDAARADDARQLFVL
AGAAEEGFMTAELAGVIKRLWKDSGVQACFNRSREYQLNDSAAYYLNDLD
RIAQPNYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFDVGGQRSERKK
WIHCFEGVTAIIFCVALSDYDLVLAEDEEMNRMHESMKLFDSICNNKWFT
DTSIILFLNKKDLFEEKIKKSPLTICYPEYAGSNTYEEAAAYIQCQFEDL
NKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF
Ligand information
Ligand ID
GDP
InChI
InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
InChIKey
QGWNDRXFNXRZMB-UUOKFMHZSA-N
SMILES
Software
SMILES
OpenEye OEToolkits 1.7.6
c1nc2c(n1C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
CACTVS 3.385
NC1=Nc2n(cnc2C(=O)N1)[C@@H]3O[C@H](CO[P](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
CACTVS 3.385
NC1=Nc2n(cnc2C(=O)N1)[CH]3O[CH](CO[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 12.01
O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c2N=C(N)NC1=O)C(O)C3O
OpenEye OEToolkits 1.7.6
c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
Formula
C10 H15 N5 O11 P2
Name
GUANOSINE-5'-DIPHOSPHATE
ChEMBL
CHEMBL384759
DrugBank
DB04315
ZINC
ZINC000008215481
PDB chain
1agr Chain D Residue 355 [
Download ligand structure
] [
Download structure with residue number starting from 1
] [
View ligand structure
]
Receptor-Ligand Complex Structure
Global view
Local view
Structure summary
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
PDB
1agr
Structure of RGS4 bound to AlF4--activated G(i alpha1): stabilization of the transition state for GTP hydrolysis.
Resolution
2.8 Å
Binding residue
(original residue number in PDB)
E43 S44 G45 K46 S47 T48 L175 R176 T177 R178 N269 K270 D272 L273 C325 A326 T327
Binding residue
(residue number reindexed from 1)
E33 S34 G35 K36 S37 T38 L165 R166 T167 R168 N259 K260 D262 L263 C315 A316 T317
Annotation score
4
Enzymatic activity
Catalytic site (original residue number in PDB)
E43 T48 D200
Catalytic site (residue number reindexed from 1)
E33 T38 D190
Enzyme Commision number
?
Gene Ontology
Molecular Function
GO:0000287
magnesium ion binding
GO:0001664
G protein-coupled receptor binding
GO:0003924
GTPase activity
GO:0005515
protein binding
GO:0005525
GTP binding
GO:0016787
hydrolase activity
GO:0019001
guanyl nucleotide binding
GO:0019003
GDP binding
GO:0031683
G-protein beta/gamma-subunit complex binding
GO:0031749
D2 dopamine receptor binding
GO:0031821
G protein-coupled serotonin receptor binding
GO:0032794
GTPase activating protein binding
GO:0046872
metal ion binding
Biological Process
GO:0007165
signal transduction
GO:0007186
G protein-coupled receptor signaling pathway
GO:0007188
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO:0043949
regulation of cAMP-mediated signaling
GO:0050805
negative regulation of synaptic transmission
GO:0051301
cell division
GO:0060236
regulation of mitotic spindle organization
GO:0099645
neurotransmitter receptor localization to postsynaptic specialization membrane
GO:1904322
cellular response to forskolin
GO:1904778
positive regulation of protein localization to cell cortex
Cellular Component
GO:0005634
nucleus
GO:0005737
cytoplasm
GO:0005813
centrosome
GO:0005834
heterotrimeric G-protein complex
GO:0005856
cytoskeleton
GO:0005886
plasma membrane
GO:0005938
cell cortex
GO:0030496
midbody
GO:0032991
protein-containing complex
GO:0098794
postsynapse
GO:0098978
glutamatergic synapse
View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB
RCSB:1agr
,
PDBe:1agr
,
PDBj:1agr
PDBsum
1agr
PubMed
9108480
UniProt
P10824
|GNAI1_RAT Guanine nucleotide-binding protein G(i) subunit alpha-1 (Gene Name=Gnai1)
[
Back to BioLiP
]