Structure of PDB 8b6g Chain CB Binding Site BS03

Receptor Information

>8b6g Chain CB (length=285) Species: 5911 (Tetrahymena thermophila)

AESNDATSICLESISGTIKGLQKANYVVEHNPNLTSEEKKHLKQFLVYRY
NPADPHDQPKYVSYWCDIKKFPPMFLDAILYIKNELDPTLSIRRSCREGI
CGSCAVNCDGLHTLACISGFNRDLSKPTIITPLGHMFILKDLVVDMTNFY
AQYKMIEPYLKRKTPKPDANKEYPQSPEQRALLDGLYECVLCAACSTSCP
SYWWHPDRYLGPAILQQAYRWIVDSRDEYTQERIERIAEDVRLDDCQQIG
MCSFTCPKGLNPQLSLKNLMDMVKDFRQKRIEQEV

Ligand information

• Ligand ID: F3S
• InChI: InChI=1S/3Fe.4S
• InChIKey: FCXHZBQOKRZXKS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.385: S1[Fe]S[Fe]2S[Fe]1S2
  OpenEye OEToolkits 2.0.7: S1[Fe]2S[Fe]3[S]2[Fe]1S3
• Formula: Fe3 S4
• Name: FE3-S4 CLUSTER
• PDB chain: 8b6g Chain CB Residue 1002

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8b6g Structural basis of mitochondrial membrane bending by the I-II-III 2 -IV 2 supercomplex.
• Resolution: 3.0 Å
• Binding residue (original residue number in PDB): C225 S227 C272 Q273 Q274 I275 G276 M277 C278
• Binding residue (residue number reindexed from 1): C199 S201 C246 Q247 Q248 I249 G250 M251 C252
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 1.3.5.1: succinate dehydrogenase.

Gene Ontology

Molecular Function

• GO:0008177 succinate dehydrogenase (quinone) activity
• GO:0009055 electron transfer activity
• GO:0016491 oxidoreductase activity
• GO:0051536 iron-sulfur cluster binding
• GO:0051537 2 iron, 2 sulfur cluster binding
• GO:0051538 3 iron, 4 sulfur cluster binding

Biological Process

• GO:0006099 tricarboxylic acid cycle
• GO:0009060 aerobic respiration
• GO:0022904 respiratory electron transport chain

Cellular Component

• GO:0005743 mitochondrial inner membrane

External links

• PDB: RCSB:8b6g, PDBe:8b6g, PDBj:8b6g
• PDBsum: 8b6g
• PubMed: 36949187
• UniProt: I7M403