Structure of PDB 7miz Chain C4 Binding Site BS03

Receptor Information

>7miz Chain C4 (length=428) Species: 5811 (Toxoplasma gondii)

MREVISIHVGQAGIQIGNACWELFCLEHGIQPDGQMPDAFNTFFSETGAG
KHVPRCVFLDLEPTVVDEVRTGTYRHLFHPEQLISGKEDAANNFARGHYT
IGKEIVDLSLDRIRKLADNCTGLQGFLMFNAVGGGTGSGLGCLLLERLSV
DYGKKSKLNFCSWPSPQVSTAVVEPYNSVLSTHSLLEHTDVAVMLDNEAI
YDICRRNLDIERPTYTNLNRLIAQVISSLTASLRFDGALNVDVTEFQTNL
VPYPRIHFMLSSYAPIISAEKAYHEQLSVAEITNSAFEPASMMAKCDPRH
GKYMACCLMYRGDVVPKDVNAAVATIKTKRTIQFVDWCPTGFKCGINYQP
PTVVPGGDLAKVMRAVCMISNSTAIAEVFSRMDHKFDLMYAKRAFVHWYV
GEGMEEGEFSEAREDLAALEKDYEEVGI

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 7miz Chain C4 Residue 502

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7miz Cryo-EM structure of cortical microtubules from human parasite Toxoplasma gondii identifies their microtubule inner proteins.
• Resolution: 3.4 Å
• Binding residue (original residue number in PDB): Q11 D69 E71 D98
• Binding residue (residue number reindexed from 1): Q11 D60 E62 D89
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.6.5.-

Gene Ontology

Molecular Function

• GO:0005200 structural constituent of cytoskeleton
• GO:0005525 GTP binding
• GO:0016787 hydrolase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0000226 microtubule cytoskeleton organization
• GO:0000278 mitotic cell cycle
• GO:0007017 microtubule-based process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005856 cytoskeleton
• GO:0005874 microtubule

External links

• PDB: RCSB:7miz, PDBe:7miz, PDBj:7miz
• PDBsum: 7miz
• PubMed: 34031406
• UniProt: P10873|TBA_TOXGO Tubulin alpha chain