Structure of PDB 8z3s Chain C Binding Site BS03

Receptor Information
>8z3s Chain C (length=900) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVGWMTSVKDWAGVMIS
AQTLTGRVLVVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAF
NVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSWLGL
RFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHLV
ENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVF
FILGGLAMFASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHITLESV
SNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVL
NPHDLARVKIESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRI
ITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQGLSTM
LANLFSMRSFIKIEEDTWQKYYLEGVSNEMYTEYLSSAFVGLSFPTVCEL
CFVKLKLLMIAIEYKSANRESRILINPGNHLKIQEGTLGFFIASDAKEVK
RAFFYCKACNVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVLSGHVVVC
IFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHN
FPKVSILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECIL
ASLNIKSMQFDDSITTGVNIPIITELVNDTNVQFLDQDDDDDPDTELYLT
QPFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAEE
NALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKT
YNMLCFGIYRLRDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFD
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain8z3s Chain C Residue 1206 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8z3s Activation mechanism and novel binding site of the BKCa channel activator CTIBD
Resolution3.9 Å
Binding residue
(original residue number in PDB)		Q947 F948 L949 D950 D953
Binding residue
(residue number reindexed from 1)		Q733 F734 L735 D736 D739
Annotation score1
Gene Ontology
Molecular Function
GO:0003779 actin binding
GO:0005249 voltage-gated potassium channel activity
GO:0005267 potassium channel activity
GO:0005515 protein binding
GO:0015269 calcium-activated potassium channel activity
GO:0046872 metal ion binding
GO:0060072 large conductance calcium-activated potassium channel activity
Biological Process
GO:0001666 response to hypoxia
GO:0006813 potassium ion transport
GO:0006970 response to osmotic stress
GO:0030007 intracellular potassium ion homeostasis
GO:0034465 response to carbon monoxide
GO:0042311 vasodilation
GO:0042391 regulation of membrane potential
GO:0043065 positive regulation of apoptotic process
GO:0045794 negative regulation of cell volume
GO:0051592 response to calcium ion
GO:0060073 micturition
GO:0060083 smooth muscle contraction involved in micturition
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0008076 voltage-gated potassium channel complex
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0034702 monoatomic ion channel complex
GO:0045211 postsynaptic membrane

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8z3s, PDBe:8z3s, PDBj:8z3s
PDBsum8z3s
PubMed39089879
UniProtQ12791|KCMA1_HUMAN Calcium-activated potassium channel subunit alpha-1 (Gene Name=KCNMA1)

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