Structure of PDB 8th5 Chain C Binding Site BS03

Receptor Information
>8th5 Chain C (length=125) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KPSPLLVGREFVRQYYTLLNQAPDMLHRFYGKNSSYVHADAVYGQKEIHR
KVMSQNFTNCHTKIRHVDAHATLNDGVVVQVMGLLSNNNQALRRFMQTFV
LAPEGSVANKFYVHNDIFRYQDEVF
Ligand information
>8th5 Chain O (length=9) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ALRITFGGP
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8th5 Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication.
Resolution2.62 Å
Binding residue
(original residue number in PDB)		R17 Q18
Binding residue
(residue number reindexed from 1)		R13 Q14
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
External links
PDB RCSB:8th5, PDBe:8th5, PDBj:8th5
PDBsum8th5
PubMed38492217
UniProtQ13283|G3BP1_HUMAN Ras GTPase-activating protein-binding protein 1 (Gene Name=G3BP1)

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