Structure of PDB 8skt Chain C Binding Site BS03
Receptor Information
>8skt Chain C (length=337) Species:
10090
(Mus musculus) [
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DKLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQSEFKGVEQLNTGSY
YEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFPLSHFVLSATK
MLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNPEEISVDIILA
LESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKQGETWRLSFSH
TEKYILNNHGIEKTCCESSGAKCCRKECLKLMKYLLEQLKKEFQELDAFC
SYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDKLLAFFLECLRTEKLDHYF
IPKFNLFSQELIDRKSKEFLSKKIEYERNNGFPIFDK
Ligand information
>8skt Chain J (length=18) [
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atctgtacatgtacagat
Receptor-Ligand Complex Structure
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PDB
8skt
Structure of ternary complex of mouse cGAS with dsDNA and bound ATP with 5 mM Mn2+
Resolution
2.69 Å
Binding residue
(original residue number in PDB)
R161 S165 A168 Y200
Binding residue
(residue number reindexed from 1)
R14 S18 A21 Y50
Enzymatic activity
Enzyme Commision number
2.7.7.86
: cyclic GMP-AMP synthase.
External links
PDB
RCSB:8skt
,
PDBe:8skt
,
PDBj:8skt
PDBsum
8skt
PubMed
38740774
UniProt
Q8C6L5
|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)
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