Structure of PDB 8sj2 Chain C Binding Site BS03
Receptor Information
>8sj2 Chain C (length=343) Species:
10090
(Mus musculus) [
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KLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNTG
SYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFPLSHFEVLS
ATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNPEEISVDI
ILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKNAKQGETW
RLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLMKYLLEQLKKEFQ
ELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDKLLAFFLECLRTE
KLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNGFPIFDK
Ligand information
>8sj2 Chain J (length=18) [
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atctgtacatgtacagat
Receptor-Ligand Complex Structure
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PDB
8sj2
Structure of ternary complex of cGAS with dsDNA and bound ATP and 2'-dGTP
Resolution
2.23 Å
Binding residue
(original residue number in PDB)
R161 S165 A168 N196 Y200 Y201
Binding residue
(residue number reindexed from 1)
R13 S17 A20 N48 Y52 Y53
Enzymatic activity
Enzyme Commision number
2.7.7.86
: cyclic GMP-AMP synthase.
External links
PDB
RCSB:8sj2
,
PDBe:8sj2
,
PDBj:8sj2
PDBsum
8sj2
PubMed
38740774
UniProt
Q8C6L5
|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)
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