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Receptor Information

>8ptx Chain C (length=538) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SPAELMMLTIGDVIKQLIEAHEQGKDIDLNKVKTKTAAKYGLSAQPRLVD
IIAAVPPQYRKVLMPKLKAKPIRTASGIAVVAVMCKPHRCPHISFTGNIC
VYCPGGPDSDFEYSTQSYTGYEPTSMRAIRARYDPFLQTRHRIEQLKQLG
HSVDKVEFIVMGGTFMALPEEYRDYFIRNLHDALSGHTSNNIYEAVKYSE
RSLTKCIGITIETRPDYCMKRHLSDMLTYGCTRLEIGVQSVYEDVARDTN
RGHTVKAVCESFHLAKDSGFKVVAHMMPDLPNVGLERDIEQFTEFFENPA
FRPDGLKLYPTLVIRGTGLYELWKSGRYKSYSPSDLVELVARILALVPPW
TRVYRVQRDIPMPLVSSGVEHGNLRELALARMKDLGIQCRDVRTREVGIQ
EIHHKVRPYQVELVRRDYVANGGWETFLSYEDPDQDILIGLLRLRKCSEE
TFRFELGGGVSIVRELHVYGSVVPVSSRDPTKFQHQGFGMLLMEEAERIA
REEHGSGKIAVISGVGTRNYYRKIGYRLQGPYMVKMLK

Ligand ID

ACO

InChI

InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/t13-,16-,17-,18+,22-/m1/s1

InChIKey

ZSLZBFCDCINBPY-ZSJPKINUSA-N

SMILES

Software	SMILES
OpenEye OEToolkits 1.5.0	CC(=O)SCCNC(=O)CCNC(=O)[C@@H](C(C)(C)CO[P@](=O)(O)O[P@@](=O)(O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)n2cnc3c2ncnc3N)O)OP(=O)(O)O)O
CACTVS 3.341	CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)CO[P@@](O)(=O)O[P@](O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O[P](O)(O)=O)n2cnc3c(N)ncnc23
ACDLabs 10.04	O=C(SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3OP(=O)(O)O)C
CACTVS 3.341	CC(=O)SCCNC(=O)CCNC(=O)[CH](O)C(C)(C)CO[P](O)(=O)O[P](O)(=O)OC[CH]1O[CH]([CH](O)[CH]1O[P](O)(O)=O)n2cnc3c(N)ncnc23
OpenEye OEToolkits 1.5.0	CC(=O)SCCNC(=O)CCNC(=O)C(C(C)(C)COP(=O)(O)OP(=O)(O)OCC1C(C(C(O1)n2cnc3c2ncnc3N)O)OP(=O)(O)O)O

Formula

C23 H38 N7 O17 P3 S

Name

ACETYL COENZYME *A

PDB chain

8ptx Chain C Residue 603 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8ptx Cryo-EM structure of human Elp123 in complex with tRNA, acetyl-CoA, 5'-deoxyadenosine and methionine
Resolution	2.87 Å
Binding residue (original residue number in PDB)	I216 L475 S485 R487 Q493 H494 G496 M499 G525 T526 Y529 Y530
Binding residue (residue number reindexed from 1)	I207 L466 S476 R478 Q484 H485 G487 M490 G516 T517 Y520 Y521
Annotation score	4

Enzyme Commision number

2.3.1.311: tRNA carboxymethyluridine synthase.

	Molecular Function
GO:0000049	tRNA binding
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0008607	phosphorylase kinase regulator activity
GO:0016407	acetyltransferase activity
GO:0016746	acyltransferase activity
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups
GO:0046872	metal ion binding
GO:0051536	iron-sulfur cluster binding
GO:0051539	4 iron, 4 sulfur cluster binding
GO:0106261	tRNA uridine(34) acetyltransferase activity

	Biological Process
GO:0001764	neuron migration
GO:0002098	tRNA wobble uridine modification
GO:0002926	tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation
GO:0006357	regulation of transcription by RNA polymerase II
GO:0006417	regulation of translation
GO:0007399	nervous system development
GO:0007417	central nervous system development
GO:0008033	tRNA processing
GO:0030335	positive regulation of cell migration

	Cellular Component
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0033588	elongator holoenzyme complex

PDB	RCSB:8ptx, PDBe:8ptx, PDBj:8ptx
PDBsum	8ptx
PubMed	38750017
UniProt	Q9H9T3\|ELP3_HUMAN Elongator complex protein 3 (Gene Name=ELP3)

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Structure of PDB 8ptx Chain C Binding Site BS03