Structure of PDB 8hfv Chain C Binding Site BS03

Receptor Information
>8hfv Chain C (length=218) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
APRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSE
QNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKY
NPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGI
YFEPDCSSEDMDHGVLVVGYGFEESDNNKYWLVKNSWGEEWGMGGYVKMA
KDRRNHCGIASAASYPTV
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8hfv Chain C Residue 306 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8hfv Crystal structure of CTSL in complex with K777
Resolution2.1 Å
Binding residue
(original residue number in PDB)		K17 E50 E86
Binding residue
(residue number reindexed from 1)		K17 E50 E86
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.22.15: cathepsin L.
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:8hfv, PDBe:8hfv, PDBj:8hfv
PDBsum8hfv
PubMed37990007
UniProtP07711|CATL1_HUMAN Procathepsin L (Gene Name=CTSL)

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