Structure of PDB 8g5h Chain C Binding Site BS03

Receptor Information
>8g5h Chain C (length=344) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDME
YTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVA
HNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGS
YAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGE
YVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFG
VTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNY
FTKRGYAWDGKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLN
Ligand information
Ligand IDR5R
InChIInChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3
InChIKeyZAFYATHCZYHLPB-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7Cc1ccc(cc1)c2c(n3cc(ccc3n2)C)CC(=O)N(C)C
CACTVS 3.385CN(C)C(=O)Cc1n2cc(C)ccc2nc1c3ccc(C)cc3
ACDLabs 12.01CN(C)C(=O)Cc1c(nc2ccc(C)cn12)c1ccc(C)cc1
FormulaC19 H21 N3 O
NameZolpidem
ChEMBLCHEMBL911
DrugBankDB00425
ZINCZINC000000003876
PDB chain8g5h Chain C Residue 602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8g5h Cryo-EM structures reveal native GABA A receptor assemblies and pharmacology.
Resolution2.89 Å
Binding residue
(original residue number in PDB)		H101 Y159 S204 T206 Y209
Binding residue
(residue number reindexed from 1)		H93 Y151 S196 T198 Y201
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0004890 GABA-A receptor activity
GO:0005216 monoatomic ion channel activity
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006821 chloride transport
GO:0007214 gamma-aminobutyric acid signaling pathway
GO:0034220 monoatomic ion transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8g5h, PDBe:8g5h, PDBj:8g5h
PDBsum8g5h
PubMed37730991
UniProtP62812|GBRA1_MOUSE Gamma-aminobutyric acid receptor subunit alpha-1 (Gene Name=Gabra1)

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