Structure of PDB 8ecc Chain C Binding Site BS03
Receptor Information
>8ecc Chain C (length=343) Species:
10090
(Mus musculus) [
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KLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNTG
SYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFNPLSHFLVL
SATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNPEEISVD
IILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKNAQGETW
RLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLMKYLLEQLKKEFQ
ELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDKLLAFFLECLRTE
KLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNGFPIFDK
Ligand information
>8ecc Chain I (length=18) [
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atctgtacatgtacagat
Receptor-Ligand Complex Structure
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PDB
8ecc
Structure of Ternary Complex of cGAS with dsDNA and Bound 5-pppI(2,5)pA
Resolution
2.44 Å
Binding residue
(original residue number in PDB)
R158 L159 K160 R161 K184 H203 K395
Binding residue
(residue number reindexed from 1)
R10 L11 K12 R13 K36 H55 K232
Enzymatic activity
Enzyme Commision number
2.7.7.86
: cyclic GMP-AMP synthase.
External links
PDB
RCSB:8ecc
,
PDBe:8ecc
,
PDBj:8ecc
PDBsum
8ecc
PubMed
UniProt
Q8C6L5
|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)
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