Structure of PDB 8ecc Chain C Binding Site BS03

Receptor Information
>8ecc Chain C (length=343) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNTG
SYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFNPLSHFLVL
SATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNPEEISVD
IILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKNAQGETW
RLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLMKYLLEQLKKEFQ
ELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDKLLAFFLECLRTE
KLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNGFPIFDK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8ecc Structure of Ternary Complex of cGAS with dsDNA and Bound 5-pppI(2,5)pA
Resolution2.44 Å
Binding residue
(original residue number in PDB)
R158 L159 K160 R161 K184 H203 K395
Binding residue
(residue number reindexed from 1)
R10 L11 K12 R13 K36 H55 K232
Enzymatic activity
Enzyme Commision number 2.7.7.86: cyclic GMP-AMP synthase.
External links
PDB RCSB:8ecc, PDBe:8ecc, PDBj:8ecc
PDBsum8ecc
PubMed
UniProtQ8C6L5|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)

[Back to BioLiP]