Structure of PDB 8e82 Chain C Binding Site BS03

Receptor Information
>8e82 Chain C (length=1095) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSSNNSVPGAPNRVSFAKLREPLEVPGLLDVQTDSFEWLIGSPRWRESAA
ERGDVNPVGGLEEVLYELSPIEDFSGSMSLSFSDPRFDDVKAPVDECKDK
DMTYAAPLFVTAEFINNNTGEIKSQTVFMGDFPMMTEKGTFIINGTERVV
VSQLVRSPGVYFDETIDKSTDKTLHSVKVIPSRGAWLEFDVDKRDTVGVR
IDRKRRQPVTVLLKALGWTSEQIVERFGFSEIMRSTLEKDNTVGTDEALL
DIYRKLRPGEPPTKESAQTLLENLFFKEKRYDLARVGRYKVNKKLGLHVG
EPITSSTLTEEDVVATIEYLVRLHEGQTTMTVPGGVEVPVETDDIDHFGN
RRLRTVGELIQNQIRVGMSRMERVVRERMTTQDVEAITPQTLINIRPVVA
AIKEFFGTSQLSQFMDQNNPLSGLTHKRRLSALGPGGLSRERAGLEVRDV
HPSHYGRMCPIETPEGPNIGLIGSLSVYARVNPFGFIETPYRKVVDGVVS
DEIVYLTADEEDRHVVAQANSPIDADGRFVEPRVLVRRKAGEVEYVPSSE
VDYMDVSPRQMVSVATAMIPFLEHDDANRALMGANMQRQAVPLVRSEAPL
VGTGMELRAAIDAGDVVVAEESGVIEEVSADYITVMHDNGTRRTYRMRKF
ARSNHGTCANQCPIVDAGDRVEAGQVIADGPCTDDGEMALGKNLLVAIMP
WEGHNYEDAIILSNRLVEEDVLTSIHIEEHEIDARDTKLGAEEITRDIPN
ISDEVLADLDERGIVRIGAEVRDGDILVGKVTPKGREVRDTSLKVPHGES
GKVIGIRVFSREDEDELPAGVNELVRVYVAQKRKISDGDKLAGRHGNKGV
IGKILPVEDMPFLADGTPVDIILNTHGVPRRMNIGQILETHLGWCAHSGW
KVDAAKGVPDWAARLPDELLEAQPNAIVSTPVFDGAQEAELQGLLSCTLP
NRDGDVLVDADGKAMLFDGRSGEPFPYPVTVGYMYIMKLHHLVDDKIHAR
STGPYSMITQQPLGGKAQFGGQRFGEMECWAMQAYGAAYTLQELLTIKSD
DTVGRVKVYEAIVKGENIPEPGIPESFKVLLKELQSLCLNVEVLS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8e82 Structural and functional basis of the universal transcription factor NusG pro-pausing activity in Mycobacterium tuberculosis.
Resolution3.03 Å
Binding residue
(original residue number in PDB)		Q435 R465 P489 Q614 K884 K892 H1035 M1051 L1057 Q1062
Binding residue
(residue number reindexed from 1)		Q410 R440 P464 Q589 K840 K848 H991 M1007 L1013 Q1018
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0046677 response to antibiotic
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

View graph for
Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8e82, PDBe:8e82, PDBj:8e82
PDBsum8e82
PubMed37116494
UniProtP9WGY9|RPOB_MYCTU DNA-directed RNA polymerase subunit beta (Gene Name=rpoB)

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