Structure of PDB 8a7d Chain C Binding Site BS03

Receptor Information
>8a7d Chain C (length=921) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SRALYFSGRGEQLRLRADLELPRDAFTLQVWLRAEGGQRSPAVITGLYDK
CSYISRDRGWVVGIHTISDQDNKDPRYFFSLKTDRARQVTTINAHRSYLP
GQWVYLAATYDGQFMKLYVNGAQVATSGEQVGGIFSPLTQKCKVLMLGGS
ALNHNYRGYIEHFSLWKVARTQREILSDMETHGAHTALPQLLLQENWDNV
KHAWSPMKDGSSPKVEFSNAHGFLLDTSLEPPLCGQTLCDNTEVIASYNQ
LSSFRQPKVVRYRVVNLYEDDHKNPTVTREQVDFQHHQLAEAFKQYNISW
ELDVLEVSNSSLRRRLILANCDISKIGDENCDPECNHTLTGHDGGDCRHL
RHPAFVKKQHNGVCDMDCNYERFNFDGGECCDPEITNVTQTCFDPDSPHR
AYLDVNELKNILKLDGSTHLNIFFAKSSEEELAGVATWPWDKEALMHLGG
IVLNPSFYGMPGHTHTMIHQIGHSLGLYHVFRGISEIQSCSDPCMETEPS
FETGDLCNDTNPAPKHKSCGDPGPGNDTCGFHSFFNTPYNNFMSYADDDC
TDSFTPNQVARMHCYLDLVYQGWQPSRKPAPVALAPQVLGHTTDSVTLEW
FPPIDGHFFERELGSACHLCLEGRILVQYASNASSPMPCSPSGHWSPREA
EGHPDVEQPCKSSVRTWSPNSAVNPHTVPPACPEPQGCYLELEFLYPLVP
ESLTIWVTFVSTDWDSSGAVNDIKLLAVSGKNISLGPQNVFCDVPLTIRL
WDVGEEVYGIQIYTLDEHLEIDAAMLTSTADTPLCLQCKPLKYKVVRDPP
LQMDVASILHLNRKFVDMDLNLGSVYQYWVITISGTEESEPSPAVTYIHG
SGYCGDGIIQKDQGEQCDDMNKINGDGCSLFCRQEVSFNCIDEPSRCYFH
DGDGVCEEFEQKTSIKDCGVY
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain8a7d Chain C Residue 1710 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8a7d Structure of the proteolytic enzyme PAPP-A with the endogenous inhibitor stanniocalcin-2 reveals its inhibitory mechanism.
Resolution3.06 Å
Binding residue
(original residue number in PDB)		E589 D598 C600 T603
Binding residue
(residue number reindexed from 1)		E496 D505 C507 T510
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.24.79: pappalysin-1.
Gene Ontology
Molecular Function
GO:0004175 endopeptidase activity
GO:0004222 metalloendopeptidase activity
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0007166 cell surface receptor signaling pathway
GO:0007565 female pregnancy
GO:0030163 protein catabolic process
GO:0032354 response to follicle-stimulating hormone
GO:0071548 response to dexamethasone
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8a7d, PDBe:8a7d, PDBj:8a7d
PDBsum8a7d
PubMed36257932
UniProtQ13219|PAPP1_HUMAN Pappalysin-1 (Gene Name=PAPPA)

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