Structure of PDB 7xr6 Chain C Binding Site BS03

Receptor Information
>7xr6 Chain C (length=424) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RLCDKLGKNLLLTLTVFGVILGAVCGGLLRLASPIHPDVVMLIAFPGDIL
MRMLKMLILPLIISSLITGLSGLDAKASGRLGTRAMVYYMSTTIIAAVLG
VILVLAIHPGNPKVSSLDAFLDLIRNLFPENLVQACFQQIQTVTKVIKKG
LEFKDGMNVLGLIGFFIAFGIAMGKMGDQAKLMVDFFNILNEIVMKLVIM
IMWYSPLGIACLICGKIIAIKDLEVVARQLGMYMVTVIIGLIIHGGIFLP
LIYFVVTRKNPFSFFAGIFQAWITALGTASSAGTLPVTFRCLEENLGIDK
RVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVVLDGGQIVTVSLTAT
LASVGAASIPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTSVNV
VGDSFGAGIVYHLSKSELDTIDSQ
Ligand information
Ligand IDXKJ
InChIInChI=1S/C18H36O6/c1-2-3-4-5-6-7-8-9-10-11-12-23-18-17(22)16(21)15(20)14(13-19)24-18/h14-22H,2-13H2,1H3/t14-,15-,16+,17-,18-/m1/s1
InChIKeyPYIDGJJWBIBVIA-UYTYNIKBSA-N
SMILES
SoftwareSMILES
CACTVS 3.385CCCCCCCCCCCCO[CH]1O[CH](CO)[CH](O)[CH](O)[CH]1O
ACDLabs 12.01C(O)C1C(C(O)C(C(O1)OCCCCCCCCCCCC)O)O
OpenEye OEToolkits 2.0.7CCCCCCCCCCCCO[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)O
OpenEye OEToolkits 2.0.7CCCCCCCCCCCCOC1C(C(C(C(O1)CO)O)O)O
CACTVS 3.385CCCCCCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
FormulaC18 H36 O6
Namedodecyl beta-D-glucopyranoside
ChEMBLCHEMBL4068837
DrugBank
ZINCZINC000095713698
PDB chain7xr6 Chain C Residue 613 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7xr6 Structural basis of ligand binding modes of human EAAT2.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		V51 I55 W472
Binding residue
(residue number reindexed from 1)		V16 I20 W389
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005313 L-glutamate transmembrane transporter activity
GO:0005314 high-affinity L-glutamate transmembrane transporter activity
GO:0005515 protein binding
GO:0008509 monoatomic anion transmembrane transporter activity
GO:0015175 neutral L-amino acid transmembrane transporter activity
GO:0015179 L-amino acid transmembrane transporter activity
GO:0015293 symporter activity
GO:0015501 glutamate:sodium symporter activity
GO:0033229 cysteine transmembrane transporter activity
GO:0046872 metal ion binding
Biological Process
GO:0006750 glutathione biosynthetic process
GO:0006811 monoatomic ion transport
GO:0006836 neurotransmitter transport
GO:0006865 amino acid transport
GO:0007268 chemical synaptic transmission
GO:0007399 nervous system development
GO:0007632 visual behavior
GO:0009410 response to xenobiotic stimulus
GO:0009416 response to light stimulus
GO:0009611 response to wounding
GO:0015804 neutral amino acid transport
GO:0015813 L-glutamate transmembrane transport
GO:0021537 telencephalon development
GO:0030534 adult behavior
GO:0035264 multicellular organism growth
GO:0043200 response to amino acid
GO:0046326 positive regulation of D-glucose import
GO:0070207 protein homotrimerization
GO:0070633 transepithelial transport
GO:0070778 L-aspartate transmembrane transport
GO:0070779 D-aspartate import across plasma membrane
GO:0071314 cellular response to cocaine
GO:0098656 monoatomic anion transmembrane transport
GO:0098712 L-glutamate import across plasma membrane
GO:0098810 neurotransmitter reuptake
GO:0140009 L-aspartate import across plasma membrane
GO:0150104 transport across blood-brain barrier
GO:1903712 cysteine transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0030424 axon
GO:0030673 axolemma
GO:0031982 vesicle
GO:0042734 presynaptic membrane
GO:0044297 cell body
GO:0044306 neuron projection terminus
GO:0045121 membrane raft
GO:0045202 synapse
GO:0097449 astrocyte projection
GO:0098796 membrane protein complex
GO:0098978 glutamatergic synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7xr6, PDBe:7xr6, PDBj:7xr6
PDBsum7xr6
PubMed35680945
UniProtP43004|EAA2_HUMAN Excitatory amino acid transporter 2 (Gene Name=SLC1A2)

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