Structure of PDB 7wnh Chain C Binding Site BS03

Receptor Information
>7wnh Chain C (length=313) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRR
RNRCQYCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSPPVSLISALVRAHV
DSNPAMTSLDYSRFQANPDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADL
PKADQDLLFESAFLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVRGFG
EWIDSIVEFSSNLQNMNIDISAFSCIAALAMVTERHGLKEPKRVEELQNK
IVNCLKDHVTFNNGNYLSKLLGKLPELRTLCTQGLQRIFYLKLEDLVPPP
AIIDKLFLDTLPF
Ligand information
Receptor-Ligand Complex Structure
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PDB7wnh Integrative analysis reveals structural basis for transcription activation of Nurr1 and Nurr1-RXR alpha heterodimer.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		S366 V369 R370 I500
Binding residue
(residue number reindexed from 1)		S93 V96 R97 I220
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0004879 nuclear receptor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7wnh, PDBe:7wnh, PDBj:7wnh
PDBsum7wnh
PubMed36442107
UniProtP43354|NR4A2_HUMAN Nuclear receptor subfamily 4 group A member 2 (Gene Name=NR4A2)

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