Structure of PDB 7w6l Chain C Binding Site BS03

Receptor Information
>7w6l Chain C (length=158) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PLGSKSSQYRKMKTEWKSNVYLARSRIQGLGLYAARDIEKHTMVIEYIGT
IIRNEVANRKEKLYESQNRGVYMFRMDNDHVIDATLTGGPARYINHSCAP
NCVAEVVTFERGHKIIISSSRRIQKGEELCYDYKFDFEDDQHKIPCHCGA
VNCRKWMN
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7w6l Chain C Residue 5001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7w6l Structural basis for product specificities of MLL family methyltransferases.
Resolution2.26 Å
Binding residue
(original residue number in PDB)		C4851 C4901 C4906
Binding residue
(residue number reindexed from 1)		C98 C148 C153
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.364: [histone H3]-lysine(4) N-methyltransferase.
External links
PDB RCSB:7w6l, PDBe:7w6l, PDBj:7w6l
PDBsum7w6l
PubMed36108631
UniProtQ8NEZ4|KMT2C_HUMAN Histone-lysine N-methyltransferase 2C (Gene Name=KMT2C)

[Back to BioLiP]