Structure of PDB 7w6a Chain C Binding Site BS03

Receptor Information
>7w6a Chain C (length=159) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGI
VIRSILTDKREKYYDSKGIGSSYMFRIDDSEVVDATMHGNAARFINHSCE
PNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCG
AKKCRKFLN
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7w6a Chain C Residue 4002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7w6a Structural basis for product specificities of MLL family methyltransferases.
Resolution2.21 Å
Binding residue
(original residue number in PDB)		C3910 C3958 C3960 C3965
Binding residue
(residue number reindexed from 1)		C99 C147 C149 C154
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.364: [histone H3]-lysine(4) N-methyltransferase.
External links
PDB RCSB:7w6a, PDBe:7w6a, PDBj:7w6a
PDBsum7w6a
PubMed36108631
UniProtQ03164|KMT2A_HUMAN Histone-lysine N-methyltransferase 2A (Gene Name=KMT2A)

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