Structure of PDB 7v0c Chain C Binding Site BS03
Receptor Information
>7v0c Chain C (length=341) Species:
10090
(Mus musculus) [
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KLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNTG
SYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKPLSHFLVLSA
TKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNPEEISVDII
LALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKNAQGETWRL
SFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLMKYLLEQLKKEFQEL
DAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDKLLAFFLECLRTEKL
DHYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNGFPIFDK
Ligand information
>7v0c Chain I (length=18) [
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atctgtacatgtacagat
Receptor-Ligand Complex Structure
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PDB
7v0c
Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -pppG(2 ,5 )pG
Resolution
2.57 Å
Binding residue
(original residue number in PDB)
R158 L159 K160 R161 K184 H203 K395
Binding residue
(residue number reindexed from 1)
R10 L11 K12 R13 K36 H55 K230
Enzymatic activity
Enzyme Commision number
2.7.7.86
: cyclic GMP-AMP synthase.
External links
PDB
RCSB:7v0c
,
PDBe:7v0c
,
PDBj:7v0c
PDBsum
7v0c
PubMed
UniProt
Q8C6L5
|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)
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