Structure of PDB 7uyz Chain C Binding Site BS03
Receptor Information
>7uyz Chain C (length=337) Species:
10090
(Mus musculus) [
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KLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQSEFKGVEQLNTGSYY
EHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVPLSHFVLSATKMLS
KFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNPEEISVDIILALES
KGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKNAFQGETWRLSFSH
TEKYILNNHGIEKTCCESSGAKCCRKECLKLMKYLLEQLKKEFQELDAFC
SYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDKLLAFFLECLRTEKLDHYF
IPKFNLFSQELIDRKSKEFLSKKIEYERNNGFPIFDK
Ligand information
>7uyz Chain I (length=18) [
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atctgtacatgtacagat
Receptor-Ligand Complex Structure
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PDB
7uyz
Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -pppG(2 ,5 )pG
Resolution
2.49 Å
Binding residue
(original residue number in PDB)
R158 L159 K160 R161 H203 K395
Binding residue
(residue number reindexed from 1)
R10 L11 K12 R13 H52 K226
Enzymatic activity
Enzyme Commision number
2.7.7.86
: cyclic GMP-AMP synthase.
External links
PDB
RCSB:7uyz
,
PDBe:7uyz
,
PDBj:7uyz
PDBsum
7uyz
PubMed
UniProt
Q8C6L5
|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)
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