Structure of PDB 7uhy Chain C Binding Site BS03

Receptor Information
>7uhy Chain C (length=578) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VLTGRTMHCHLDAPANAISVCRDAAQVVVAGRSIFKIYAIEEEQFVEKLN
LRVGRKPSLNLSCADVVWHQMDENLLATAATNGVVVTWNLGRPSRNKQDQ
LFTEHKRTVNKVCFHPTEAHVLLSGSQDGFMKCFDLRRKDSVSTFSGQSE
SVRDVQFSIRDYFTFASTFENGNVQLWDIRRPDRCERMFTAHNGPVFCCD
WHPEDRGWLATGGRDKMVKVWDMTTHRAKEMHCVQTIASVARVKWRPECR
HHLATCSMMVDHNIYVWDVRRPFVPAAMFEEHRDVTTGIAWRHPHDPSFL
LSGSKDSSLCQHLFRDASQPVERANPEGLCYGLFGDLAFAAKESLVAFAG
LASSALSVFETEGMRWFVDTAERYALAGRPLAELCDHNAKVARELGRNQV
AQTWTMLRIIYCSSRLPPDFFGVLVRDMLHFYAEQGDVQMAVSVLIVLGE
RVRKDIDEQTQEHWYTSYIDLLQRFRLWNVSNEVVKLSTSRAVSCLNQAS
TTLHVNCSHCKRPMSSRGWVCDRCHRCASMCAVCHHVVKGLFVWCQGCSH
GGHLQHIMKWLEGSSHCPAGCGHLCEYS
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7uhy Chain C Residue 1003 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7uhy Structure of the nutrient-sensing hub GATOR2.
Resolution3.66 Å
Binding residue
(original residue number in PDB)		C757 C760 H785 C787
Binding residue
(residue number reindexed from 1)		C545 C548 H573 C575
Annotation score4
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0046872 metal ion binding
GO:0061630 ubiquitin protein ligase activity
Biological Process
GO:0006914 autophagy
GO:0010506 regulation of autophagy
GO:0016239 positive regulation of macroautophagy
GO:0016567 protein ubiquitination
GO:0031669 cellular response to nutrient levels
GO:0032008 positive regulation of TOR signaling
GO:0034198 cellular response to amino acid starvation
GO:0085020 protein K6-linked ubiquitination
GO:1904262 negative regulation of TORC1 signaling
GO:1904263 positive regulation of TORC1 signaling
Cellular Component
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005774 vacuolar membrane
GO:0005829 cytosol
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0061700 GATOR2 complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7uhy, PDBe:7uhy, PDBj:7uhy
PDBsum7uhy
PubMed35831510
UniProtQ96S15|WDR24_HUMAN GATOR2 complex protein WDR24 (Gene Name=WDR24)

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