Structure of PDB 7tib Chain C Binding Site BS03

Receptor Information
>7tib Chain C (length=327) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SKENLPWVEKYRPETLDEVYGQNEVITTVRKFVDEGKLPHLLFYGPPGTG
KTSTIVALAREIYGKNYSNMVLELNASDDRGIDVVRNQIKDFASTRQIFS
KGFKLIILDEADAMTNAAQNALRRVIERYTKNTRFCVLANYAHKLTPALL
SRCTRFRFQPLPQEAIERRIANVLVHEKLKLSPNAEKALIELSNGDMRRV
LNVLQSCKATLDNPDEDEISDDVIYECCGAPRPSDLKAVLKSILEDDWGT
AHYTLNKVRSAKGLALIDLIEGIVKILEDYELQNEETRVHLLTKLADIEY
SISKGGNDQIQGSAVIGAIKASFENET
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain7tib Chain C Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7tib Cryo-EM structures reveal high-resolution mechanism of a DNA polymerase sliding clamp loader.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		T60 D117
Binding residue
(residue number reindexed from 1)		T52 D109
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003689 DNA clamp loader activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0000077 DNA damage checkpoint signaling
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006272 leading strand elongation
GO:0006281 DNA repair
GO:0006298 mismatch repair
GO:0007064 mitotic sister chromatid cohesion
GO:0090618 DNA clamp unloading
Cellular Component
GO:0005634 nucleus
GO:0005663 DNA replication factor C complex
GO:0005829 cytosol
GO:0031389 Rad17 RFC-like complex
GO:0031390 Ctf18 RFC-like complex
GO:0031391 Elg1 RFC-like complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7tib, PDBe:7tib, PDBj:7tib
PDBsum7tib
PubMed35179493
UniProtP38629|RFC3_YEAST Replication factor C subunit 3 (Gene Name=RFC3)

[Back to BioLiP]