Structure of PDB 7rte Chain C Binding Site BS03

Receptor Information

>7rte Chain C (length=420) Species: 10090 (Mus musculus)

SPPKRLTREAMRNYLKERGDQTVLILHAKVAQKSYGNEKRFFCPPPCVYL
MGSGWKKKKEQMERDGCSEQESQPCAFIGIGNSDQEMQQLNLEGKNYCTA
KTLYISDSDKRKHFMLSVKMFYGNSDDIGVFLSKRIKVISKPSKKKQSLK
NADLCIASGTKVALFNRLRSQTVSTRYLHVEGGNFHASSQQWGAFYIHLL
DDDESEGEEFTVRDGYIHYGQTVKLVCSVTGMALPRLIIRKVDKQTALLD
ADDPVSQLHKCAFYLKDTERMYLCLSQERIIQFQATPCPKEQNKEMINDG
ASWTIISTDKAEYTFYEGMGPVLAPVTPVPVVESLQLNDVAMLELTGQNF
TPNLRVWFGDVEAETMYRCGESMLCVVPDISAFREGWRWVRQPVQVPVTL
VRNDGVIYSTSLTFTYTPEP

Ligand information

>7rte Chain D (length=14) Species: 9606 (Homo sapiens)

KKATATTTWMVPTA

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7rte The structure, binding and function of a Notch transcription complex involving RBPJ and the epigenetic reader protein L3MBTL3.
• Resolution: 2.06 Å
• Binding residue (original residue number in PDB): N235 F236 E259 E260 F261 V263 G282 M283 A284 P286 I331 I332 Q333 F334
• Binding residue (residue number reindexed from 1): N184 F185 E208 E209 F210 V212 G231 M232 A233 P235 I280 I281 Q282 F283

Gene Ontology

Molecular Function

• GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
• GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
• GO:0003677 DNA binding
• GO:0003700 DNA-binding transcription factor activity

Biological Process

• GO:0006355 regulation of DNA-templated transcription
• GO:0006357 regulation of transcription by RNA polymerase II

Cellular Component

• GO:0005634 nucleus

External links

• PDB: RCSB:7rte, PDBe:7rte, PDBj:7rte
• PDBsum: 7rte
• PubMed: 36477367
• UniProt: P31266|SUH_MOUSE Recombining binding protein suppressor of hairless (Gene Name=Rbpj)