Structure of PDB 7rdq Chain C Binding Site BS03

Receptor Information
>7rdq Chain C (length=1111) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEIKRFGRIREVIPLPPLTEIQVESYRRALQADVPPEKRENVGIQAAFRE
TFPIEELVLDFLEYRLGEPPFPQDECREKDLTYQAPLYARLQLIHKDTGL
IKEDEVFLGHIPLMTEDGSFIINGADRVIVSQIHRSPGVYFTPDPARPGR
YIASIIPLPKRGPWIDLEVEPNGVVSMKVNKRKFPLVLLLRVLGYDQETL
ARELGAYGELVQGLMDESVFAMRPEEALIRLFTLLRPGDPPKRDKAVAYV
YGLIADPRRYDLGEAGRYKAEEKLGIRLSGRTLARFEDGEFKDEVFLPTL
RYLFALTAGVPGHEVDDIDHLGNRRIRTVGELMTDQFRVGLARLARGVRE
RMLMGSEDSLTPAKLVNSRPLEAAIREFFSRSQLSQFKDETNPLSSLRHK
RRISALGPGGLTRERAGFDVRDVHRTHYGRICPVETPEGANIGLITSLAA
YARVDELGFIRTPYRRVVGGVVTDEVVYMTATEEDRYTIAQANTPLEGNR
IAAERVVARRKGEPVIVSPEEVEFMDVSPKQVFSVNTNLIPFLEHDDANR
ALMGSNMQTQAVPLIRAQAPVVMTGLEERVVRDSLAALYAEEDGEVAKVD
GNRIVVRYEDGRLVEYPLRRFYRSNQGTALDQRPRVVVGQRVRKGDLLAD
GPASENGFLALGQNVLVAIMPFDGYNFEDAIVISEELLKRDFYTSIHIER
YEIEARDTKLGPERITRDIPHLSEAALRDLDEEGVVRIGAEVKPGDILVG
RTSFKGESEPTPEERLLRSIFGEKARDVKDTSLRVPPGEGGIVVRTVRLR
RGDPGVELKPGVREVVRVYVAQKRKLQVGDKLANRHGNKGVVAKILPVED
MPHLPDGTPVDVILNPLGVPSRMNLGQILETHLGLAGYFLGQRYISPIFD
GAKEPEIKELLAQAFEVYFGKRKGEGFGVDKREVEVLRRAEKLGLVTPGK
TPEEQLKELFLQGKVVLYDGRTGEPIEGPIVVGQMFIMKLYHMVEDKMHA
RSTGPYSLITQQPLGGKAQFGGQRFGEMEVWALEAYGAAHTLQEMLTLKS
DDIEGRNAAYEAIIKGEDVPEPSVPESFRVLVKELQALALDVQTLDEKDN
PVDIFEGLASK
Ligand information
Receptor-Ligand Complex Structure
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PDB7rdq Structural and mechanistic basis of reiterative transcription initiation.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		N187 K188 R189 Q390 R409 G414 G416 G417 L418 T419 R420 N448 K846 H999
Binding residue
(residue number reindexed from 1)		N180 K181 R182 Q383 R402 G407 G409 G410 L411 T412 R413 N441 K839 H992
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7rdq, PDBe:7rdq, PDBj:7rdq
PDBsum7rdq
PubMed35082149
UniProtQ8RQE9|RPOB_THET8 DNA-directed RNA polymerase subunit beta (Gene Name=rpoB)

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