Structure of PDB 7o9f Chain C Binding Site BS03

Receptor Information

>7o9f Chain C (length=295) Species: 224308 (Bacillus subtilis subsp. subtilis str. 168)

MGFEGLADRLQQTISKIRGKGKVSEQDVKEMMREVRLALLEADVNFKVVK
DFVKKVSERAVGQDVMKSLTPGQQVIKVVQEELTELMGGEESKIVAKRPP
TVIMMVGLQGAGKTTTSGKLANLLRKKHNRKPMLVAADIYRPAAIKQLET
LGKQLDMPVFSLGDQSPVEIAKQAIEKAKEEDYVILDTAGRLHIDHELMD
ELTNKEIANPEEIFLVVDSMTGQDAVNVAKSFNEQLGLTGVVLTKLDGDT
RGGAALSIRAVTNTPIKFAGLGEKLDALEPFHPERMASRILGMGD

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 7o9f Chain C Residue 402

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7o9f Inhibition of SRP-dependent protein secretion by the bacterial alarmone (p)ppGpp.
• Resolution: 2.51 Å
• Binding residue (original residue number in PDB): T115 R142
• Binding residue (residue number reindexed from 1): T114 R141
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.6.5.4: signal-recognition-particle GTPase.

Gene Ontology

Molecular Function

• GO:0003924 GTPase activity
• GO:0005525 GTP binding
• GO:0016887 ATP hydrolysis activity

Biological Process

• GO:0006614 SRP-dependent cotranslational protein targeting to membrane

Cellular Component

• GO:0048500 signal recognition particle

External links

• PDB: RCSB:7o9f, PDBe:7o9f, PDBj:7o9f
• PDBsum: 7o9f
• PubMed: 35217658
• UniProt: P37105|SRP54_BACSU Signal recognition particle protein (Gene Name=ffh)