Structure of PDB 7o5l Chain C Binding Site BS03

Receptor Information

>7o5l Chain C (length=413) Species: 1111708 (Synechocystis sp. PCC 6803 substr. Kazusa)

KYDIKDISLAPQGRQRIEWAAREMPVLKQIRERFAQEKPFAGIRLVACCH
VTTETANLAIALHAGGADSLLIASNPLSTQDDVAACLVADYGIPVYAIKG
EDNETYHRHVQIALDHRPNIIIDDGSDVVATLVQERQHQLSDIIGTTEET
TTGIVRLRAMFNDGVLTFPAMNVNDADTKHFYDNRYGTGQSTLDGIIRAT
NILLAGKTIVVAGYGWCGKGVAMRAKGMGADVIVTEISPVPAIEAAMDGF
RVMPMAEAAHQGDIFITVTGNKHVIRPEHFAVMKDGAIVCNSGHFDIEID
LKSLKEQAKEVKEVRNFTEQYILPNGKSIIVIGEGRLVNLAAAEGHPSAV
MDMSFANQALACEHLVKNKGQLEPGMHSIPVEVDQEIARLKLQAMGIAID
SLTPEQVEYINSW

Ligand information

• Ligand ID: RB
• InChI: InChI=1S/Rb/q+1
• InChIKey: NCCSSGKUIKYAJD-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  CACTVS 3.341
  OpenEye OEToolkits 1.5.0: [Rb+]
• Formula: Rb
• Name: RUBIDIUM ION
• PDB chain: 7o5l Chain C Residue 503

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7o5l Biochemical and structural insights into an unusual, alkali-metal-independent S-adenosyl-L-homocysteine hydrolase from Synechocystis sp. PCC 6803.
• Resolution: 1.74 Å
• Binding residue (original residue number in PDB): Y417 S420
• Binding residue (residue number reindexed from 1): Y409 S412
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.13.2.1: adenosylhomocysteinase.

Gene Ontology

Molecular Function

• GO:0004013 adenosylhomocysteinase activity
• GO:0016787 hydrolase activity

Biological Process

• GO:0006730 one-carbon metabolic process
• GO:0033353 S-adenosylmethionine cycle
• GO:0071269 L-homocysteine biosynthetic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:7o5l, PDBe:7o5l, PDBj:7o5l
• PDBsum: 7o5l
• PubMed: 35775986
• UniProt: P74008|SAHH_SYNY3 Adenosylhomocysteinase (Gene Name=ahcY)