Structure of PDB 7n7i Chain C Binding Site BS03

Receptor Information
>7n7i Chain C (length=279) Species: 413071 (Trichoderma virens Gv29-8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QVPVSVNYHFSRKCNKECLFCFHTATTSHVEKPENAKRGLTLLKQAGMKK
INFAGGEPFLYPKFLGEMIDFCKETLQLESVSIVTNGSLVKEQFLQKHGR
NIDILAVSCDSFNEATNIKIGRGSNVQKLYEIGSWCQKYDIKFKLNTVVN
KFNHLEDMNDHLNALQPFRWKCFQVLIVTGENDSDKTLRNAHSLTISDDE
FDRFCERHSSQTCLVPEPNRLMAKSYLILDEYMRFLDRNGQQPSKSILEV
GVQQALQAVFWDEEAFVERGGIYDWNKSS
Ligand information
Ligand IDUTP
InChIInChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
InChIKeyPGAVKCOVUIYSFO-XVFCMESISA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO[P@@](=O)(O)O[P@@](=O)(O)OP(=O)(O)O)O)O
CACTVS 3.341O[CH]1[CH](O)[CH](O[CH]1CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)N2C=CC(=O)NC2=O
ACDLabs 10.04O=P(O)(O)OP(=O)(O)OP(=O)(O)OCC2OC(N1C(=O)NC(=O)C=C1)C(O)C2O
OpenEye OEToolkits 1.5.0C1=CN(C(=O)NC1=O)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O
CACTVS 3.341O[C@H]1[C@@H](O)[C@@H](O[C@@H]1CO[P@](O)(=O)O[P@](O)(=O)O[P](O)(O)=O)N2C=CC(=O)NC2=O
FormulaC9 H15 N2 O15 P3
NameURIDINE 5'-TRIPHOSPHATE
ChEMBLCHEMBL336296
DrugBankDB04005
ZINCZINC000003861755
PDB chain7n7i Chain C Residue 403 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7n7i Structural Insight into the Substrate Scope of Viperin and Viperin-like Enzymes from Three Domains of Life.
Resolution3.19 Å
Binding residue
(original residue number in PDB)		N24 H26 F39 N69 K163 N165 K190 Y245 I247 R257 Y292
Binding residue
(residue number reindexed from 1)		N7 H9 F22 N52 K144 N146 K171 Y226 I228 R238 Y273
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0051607 defense response to virus

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7n7i, PDBe:7n7i, PDBj:7n7i
PDBsum7n7i
PubMed34156827
UniProtG9MQB8

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