Structure of PDB 7lo5 Chain C Binding Site BS03

Receptor Information
>7lo5 Chain C (length=1014) Species: 980427 (Deinococcus wulumuqiensis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MSLQLVKKFQKRLEDIVAYGGTRNESSVRAAFQQLLSDWAEGSGLRLITE
VTQKAVAGNNVRPDGTLKDSLQQSRGYWESKDEADTLDDEIQKKLAKGYP
RDNIIFEDSRLAVLMQNGEEVQRVDMGDAGALAGLLKLFFEFEPPQVLEF
RKAVDHFKDEMPHLLKILREAADAAEQKADYRGERDHFVEIAKEAINPDF
SPRDAREMLIQHILTGDLFTSVFDNAQYHEDNNIAQQLQQLAATFYKGPV
KRDIAERTKRYYGAIQAAAAQIADHHEKQRFLKALYENFYRAYNPAGAER
LGIFYTPGEIVRFMIEATDTLLEKHFQKELADKGVEILDPATGTGTFITE
LIDFLPKAKLEQKYREELHCNELALLPYYIANLNIEATYAQKMGRYEEFR
NIVLVDTLDNTSGLFGSVTAENLERAKRQNARPVRVIIGNPPYRANQANE
NDNNKNREYKEIDRRIKATYVAASTAQKTKLYDMYSRFLRWATDRLKEDG
IVAFVSNSSFIDSRTFDGFRKEVVKDFDHIYILDMKGNANTSGERRKREG
GNVFNDQIKVGVAVYFLVRSADTKIWYHAVPDFWRAREKLEWLKTTKFED
IEFDHIRPDAKHNWLGQVDEENDWNEFLPVADKDTKQAKGLGQERAIFKL
YSLGVVTNRDEWVYSRAEDELADKVRYFIGRYNEIIKLPLGDLMSRNWEG
DIKMTRATIADAQSRKSYSLEKNSIVPSLYRPFDVLKMYFSKNLNEMQYQ
MPSIFPKGVGENVVIALSGSPAAKPFQVLATDILPSLDLLEKTQCLPFYR
YTMNGERLNNITDYALKAFQTHYADTSISREDIFHYVYAVLHHPAYREKY
ALNLRQEFPRIPFYPEFGRWAAWGRELMALHIGFESVAPYPLKRTDEPPK
NDTPEALALAKKARLKVQRDAAKQPTGAVELDGLTTLAGIPAAAWAYKLG
NRSALEWVLERHKETTPKDATIREKFNTYRFADHKERVIDLLARVTTVSV
ETVRIVGEMPAETM
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7lo5 Coordination of phage genome degradation versus host genome protection by a bifunctional restriction-modification enzyme visualized by CryoEM.
Resolution2.86 Å
Binding residue
(original residue number in PDB)		F304 N448 P449 Y451 A484 Q485 K486 K488 N515 S521 R522 T523 F562 Q565 I566 K567 M762 Y764 Q765 P786 K807
Binding residue
(residue number reindexed from 1)		F304 N440 P441 Y443 A476 Q477 K478 K480 N507 S513 R514 T515 F554 Q557 I558 K559 M747 Y749 Q750 P771 K792
Enzymatic activity
Enzyme Commision number 2.1.1.72: site-specific DNA-methyltransferase (adenine-specific).
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0004519 endonuclease activity
GO:0008168 methyltransferase activity
GO:0008170 N-methyltransferase activity
GO:0009007 site-specific DNA-methyltransferase (adenine-specific) activity
Biological Process
GO:0009307 DNA restriction-modification system
GO:0032259 methylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7lo5, PDBe:7lo5, PDBj:7lo5
PDBsum7lo5
PubMed33826880
UniProtA0A345IJ72

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