Structure of PDB 7k5k Chain C Binding Site BS03

Receptor Information

>7k5k Chain C (length=545) Species: 5855 (Plasmodium vivax)

TTVPQVVSLDPTTIPIDYHTPIDDLSIEVKDISAEACPADEGLIVFLLNS
APKHSSSGGSGGNGGSAGSSGNGEGGAQIKINSSVKDNTINEFLKEGNME
NFTGKLGTSKSFYIANDQKKYVSLAYVGCGPANEETELEIRKVAYALVTL
LHDSKHKKVSIIFEIKIEEALFRFFLEHLFYEYVTDERFKSADKSTETDF
IKNLSLHIANADAYKGQIDKARVYFYGTYYAAQLIAAPSNYCNPVSLSNA
AVELAQKVNLECKILDVKELEELKMGAYLSVGKGSMYPNKFIHLTYKGAQ
TGASQNEKKKIALIGKGITFDSGGYNLKAAPGSMIDLMKFDMSGCAAVLG
CAYCIGTIKPDNVEVHFLSAVCENMVSKNSYRPGDIITASNGKTIEVGNT
DAEGRLTLADALVYAEKLGVDYIVDIATLTGAMLYSLGTSYAGVFGNNDQ
LINKILSSSKTSNEPVWWLPIINEYRSSLNSKYADLNNISSSVKASSVVA
SLFLKEFIENTPWAHIDIAGVSWNFKARKPKGFGVRLLTEFVLND

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 7k5k Chain C Residue 703

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7k5k Active site metals mediate an oligomeric equilibrium in Plasmodium M17 aminopeptidases.
• Resolution: 2.66 Å
• Binding residue (original residue number in PDB): D395 D475 E477
• Binding residue (residue number reindexed from 1): D321 D401 E403
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.4.11.1: leucyl aminopeptidase.
  3.4.13.-

Gene Ontology

Molecular Function

• GO:0030145 manganese ion binding
• GO:0046872 metal ion binding
• GO:0070006 metalloaminopeptidase activity

Biological Process

• GO:0006508 proteolysis
• GO:0019538 protein metabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:7k5k, PDBe:7k5k, PDBj:7k5k
• PDBsum: 7k5k
• PubMed: 33303633
• UniProt: A5K3U9|AMPL_PLAVS Leucine aminopeptidase (Gene Name=LAP)