Structure of PDB 7jm7 Chain C Binding Site BS03

Receptor Information
>7jm7 Chain C (length=683) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLKYESLDYDNSENQLFLEEERRINHTAFRTVEIKRWVICALIGILTGLV
ACFIDIVVENLAGLKYRVIKGNIDKFTEKGGLSFSLLLWATLNAAFVLVG
SVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVG
GLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVS
AGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNF
VLSIYHGNLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFN
ALNYWLTMFRIRYIHRPCLQVIEAVLVAAVTATVAFVLIYSSRDCQPLQG
GSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPLTLGLF
TLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAIWAD
PGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIV
GDVFIEGLYDMHIQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREK
VGVIVDVLSDTASNHNGFPVVEARLQGLILRSQLIVLLKHKVFVERRLRL
KDFRDAYPRFPPIQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVF
KLFRALGLRHLVVVDNRNQVVGLVTRKDLARYR
Ligand information
Ligand IDCL
InChIInChI=1S/ClH/h1H/p-1
InChIKeyVEXZGXHMUGYJMC-UHFFFAOYSA-M
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Cl-]
FormulaCl
NameCHLORIDE ION
ChEMBL
DrugBankDB14547
ZINC
PDB chain7jm7 Chain C Residue 904 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7jm7 Cryo-EM structure of the lysosomal chloride-proton exchanger CLC-7 in complex with OSTM1.
Resolution2.82 Å
Binding residue
(original residue number in PDB)		G245 E247 G512 F514 I515
Binding residue
(residue number reindexed from 1)		G155 E157 G419 F421 I422
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005247 voltage-gated chloride channel activity
GO:0005254 chloride channel activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0015108 chloride transmembrane transporter activity
GO:0015297 antiporter activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006821 chloride transport
GO:0030321 transepithelial chloride transport
GO:0055085 transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0016020 membrane
GO:0034707 chloride channel complex
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7jm7, PDBe:7jm7, PDBj:7jm7
PDBsum7jm7
PubMed32749217
UniProtP51798|CLCN7_HUMAN H(+)/Cl(-) exchange transporter 7 (Gene Name=CLCN7)

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