Structure of PDB 6wqu Chain C Binding Site BS03

Receptor Information

>6wqu Chain C (length=417) Species: 10090 (Mus musculus)

SPPKRLTREAMRNYLKERGDQTVLILHAKVAQKSYGNEKRFFCPPPCVYL
MGSGWKKKKEQMERDGCSEQESQPCAFIGIGNSDQEMQQLNLEGKNYCTA
KTLYISDSDKRKHFMLSVKMFYGNSDDIGVFLSKRIKVISKPSKKKQSLK
NADLCIASGTKVALFNRLRSQTVSTRYLHVEGGNFHASSQQWGAFYIHLL
DDDESEGEEFTVRDGYIHYGQTVKLVCSVTGMALPRLIIRKVDKQTALLD
ADDPVSQLHKCAFYLKDTERMYLCLSQERIIQFQATPCPKEQNKEMINDG
ASWTIISTDKAEYTFYEGMGPVLAPVTPVPVVESLQLVAMLELTGQNFTP
NLRVWFGDVEAETMYRCGESMLCVVPDISAFREGWRWVRQPVQVPVTLVR
NDGVIYSTSLTFTYTPE

Ligand information

>6wqu Chain D (length=15) Species: 9606 (Homo sapiens)

KREHSTLWFPEGFSL

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6wqu PIM-induced phosphorylation of Notch3 promotes breast cancer tumorigenicity in a CSL-independent fashion.
• Resolution: 2.41 Å
• Binding residue (original residue number in PDB): N235 F236 E257 G258 E259 E260 F261 T262 G282 M283 A284 P286 M322 R330 I331 I332 Q333 F334 Q335
• Binding residue (residue number reindexed from 1): N184 F185 E206 G207 E208 E209 F210 T211 G231 M232 A233 P235 M271 R279 I280 I281 Q282 F283 Q284

Gene Ontology

Molecular Function

• GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
• GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
• GO:0003677 DNA binding
• GO:0003700 DNA-binding transcription factor activity

Biological Process

• GO:0006355 regulation of DNA-templated transcription
• GO:0006357 regulation of transcription by RNA polymerase II

Cellular Component

• GO:0005634 nucleus

External links

• PDB: RCSB:6wqu, PDBe:6wqu, PDBj:6wqu
• PDBsum: 6wqu
• PubMed: 33775697
• UniProt: P31266|SUH_MOUSE Recombining binding protein suppressor of hairless (Gene Name=Rbpj)