Structure of PDB 6vel Chain C Binding Site BS03

Receptor Information
>6vel Chain C (length=209) Species: 9606,559292 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DWVIPPISCPENEKGPFPKNLVQIKSNKDKEGKVFYSITGQGADTPPVGV
FIIERETGWLKVTEPLDRERIATYTLFSHAGNAVEDPMEILITVTDQNDN
KPEFTQEVFKGSVMEGALPGTSVMEVTATDADDDVNTYNAAIAYTILSQD
PELPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQAADLQGEGLSTT
ATAVITVTD
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6vel Chain C Residue 405 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6vel Regulation of multiple dimeric states of E-cadherin by adhesion activating antibodies revealed through Cryo-EM and X-ray crystallography.
Resolution2.65 Å
Binding residue
(original residue number in PDB)		E112 E170 D201 Q202 D204 D237
Binding residue
(residue number reindexed from 1)		E11 E69 D96 Q97 D99 D132
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0031386 protein tag activity
GO:0042802 identical protein binding
GO:0044389 ubiquitin-like protein ligase binding
Biological Process
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
GO:0016925 protein sumoylation
GO:0098609 cell-cell adhesion
Cellular Component
GO:0000794 condensed nuclear chromosome
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0005940 septin ring
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6vel, PDBe:6vel, PDBj:6vel
PDBsum6vel
PubMed36157596
UniProtP12830|CADH1_HUMAN Cadherin-1 (Gene Name=CDH1);
Q12306|SMT3_YEAST Ubiquitin-like protein SMT3 (Gene Name=SMT3)

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